You lead a laboratory team in conducting innovative in-vivo research on neurodegenerative diseases, emphasizing collaboration, mentorship, and the integration of various scientific techniques to advance therapeutic development.
Anforderungen
- •PhD with 3+ years post-doctoral research
- •Accreditation for animal experimentation
- •Deep knowledge of pathophysiology related to neurodegenerative diseases
- •Fluency in handling large datasets
- •Highly motivated to learn about neurodegenerative diseases
- •Proactive and dynamic attitude
- •Excellent teamwork mindset
- •Fluency in written and oral English
- •Knowledge about aging biology
- •Experience in assessing pathophysiological cross-talk
Deine Aufgaben
- •Manage a small in vivo laboratory team.
- •Design and conduct in-vivo experiments on mice and rats.
- •Mentor and support career development of team members.
- •Research pathophysiological changes in neurons and CNS cell types.
- •Investigate synaptic dysfunction and metabolic changes in aging.
- •Collaborate with global experts on drug discovery targets.
- •Identify biomarker candidates and elucidate drug modes of action.
- •Understand cross-talk between CNS cell types and organs.
- •Integrate laboratory research with molecular and cellular techniques.
- •Present research results at team meetings and management boards.
Original Beschreibung
# Principal Scientist - In-Vivo Physiology, Diseases of Aging and Regenerative medicine (DARe)
**Basel (City)** | **Full time**
**Job Description Summary**
Location: Basel, Switzerland
Onsite, full time, #LI-onsite
About the role
We are seeking a dedicated, innovative, and skilled neuroscientist to apply their research experience in neurodegenerative diseases to study age-related pathophysiological changes in the central nervous system (CNS) leading to progressive structural and functional decline. You will join our global, dynamic research environment to enable the discovery of new medicines addressing neurodegenerative diseases of aging.
**Job Description**
Our vision is to pioneer the development of novel therapeutic approaches from an understanding of age as the greatest risk factor for neurodegeneration and associated functional decline.
The ideal candidate will have a strong background in neurodegenerative diseases, namely Alzheimer`s disease, and experience in the translational aspects of human pathophysiology with rodent model systems (in vivo/ex vivo) to enable deep insights into neuronal and other brain cell type pathobiology. As part of the Diseases of Aging and Regenerative medicine (DARe) disease area within Biomedical Research you will contribute to our global research efforts to elucidate and target the molecular mechanisms underlying neurodegenerative diseases to develop pharmacological interventions for patients.
The role involves strong collaboration across the DARe In-vivo Physiology, In-vitro Biology and Data Science teams as well as collaborating with scientists from the Neuroscience disease area to drive our research goals.
Major Accountabilities
Your responsibilities include, but are not limited to:
* Managing a small *in vivo* laboratory team, designing and conducting state-of-the-art *in-vivo* mouse and rat experiments in support of research aiming to develop novel therapeutics for age-related neurodegenerative diseases with a particular focus on Alzheimer’s disease.
* Mentoring and career development of direct reports.
* Conducting cutting edge research on the pathophysiological changes in neurons and other CNS cell types, including synaptic dysfunction, and metabolic changes in aging and disease.
* Working at the interface between *in-vitro* biology, integrated pharmacology, aging and disease research and collaborating with a wide range of scientific experts globally across Novartis Biomedical Research to deliver new and actionable therapeutic targets for drug discovery to develop innovative medicines addressing neurodegeneration.
* Supporting the identification of biomarker candidates, elucidating the mode of action of drugs and understanding cross-talk between CNS cell types and across brain subregions as well as with other organs to delineate disease trajectories and novel drug intervention strategies.
* Integrating laboratory research of *in vitro, in vivo* and *ex vivo* tissue and biofluid analyses applying a broad range of molecular and cellular techniques.
* Interpreting and presenting results in both written and oral format at project team meetings and to management decision boards.
What you’ll bring to the role:
Essential:
* PhD with 3+ years post-doctoral research in neuroscience and hands-on experience in designing and conducting experiments with rodents, documented through publications.
* Accreditation for animal experimentation (LTK1/LTK2, FELASA B or equivalent).
* Deep knowledge of human and animal pathophysiology related to neurodegenerative diseases including Alzheimer`s disease. Additional expertise in neuro-endocrine systems, metabolism and CNS tissue homeostasis is advantageous.
* Fluency in the handling and analysis of large datasets and integration of genomic, proteomic and metabolomic data into research.
* Highly motivated to learn more about targeting neurodegenerative diseases of aging and regenerative medicine.
* Proactive and dynamic attitude with a demonstrable inquisitive mindset and a proven ability to formulate, articulate, and critically evaluate scientific experiments.
* Excellent teamwork mindset and high aptitude to work and thrive in cross-disciplinary teams. High learning agility and a desire to be up to date with the latest in vivo methodology.
* Fluency in written and oral English with excellent communication skills.
Desirable requirements:
* Knowledge about aging biology.
* Experience in assessing pathophysiological cross-talk between different CNS cell types and CNS subregions as well as with peripheral organs.
**Skills Desired**
Aging Research, Alzheimer's Disease, in vivo neurosciences, Nervous System, Neurodegeneration, Neurophysiology, Neuroscience, Neuroscience Research, Physiology