You conduct hands-on experiments and contribute to the development of innovative technologies for analyzing viral vectors. You ensure compliance with GMP requirements and generate detailed reports on your findings.
Anforderungen
- •Experience with analytical ultracentrifugation
- •Knowledge of gene therapeutic modalities
- •Experience with GMP principles
- •High degree of self-motivation
- •Fluent in English and German
Deine Aufgaben
- •Scout and evaluate innovative analytical ultracentrifugation technologies.
- •Develop and implement workflows for viral vector analysis.
- •Advance science in characterizing viral vectors with the team.
- •Execute experiments, method development, and equipment qualification.
- •Validate assays under GMP requirements while testing.
- •Contribute to control and testing strategies for gene therapy vectors.
- •Interpret and evaluate data, generating analytical reports.
Deine Vorteile
Flexible time management
2092 Euro monthly salary
Reduced meal prices
On-campus fitness center
Networking opportunities
Accommodation possibility or shuttle to Munich
Original Beschreibung
# Praktikum in der analytischen Entwicklung und Qualitätskontrolle, Schwerpunkt Analytische Ultrazentrifugation (m/w/d)
**Penzberg** | **Full time**
### The Position
**Your Department and Team:**
The Analytical Development and Quality Control (ADQC) unit is located in the Gene Therapy Development Center (GTDC) in Penzberg, Germany. The ADQC department consists of 40 - 50 persons working to develop and implement novel analytical technologies for pre-clinical studies until market authorization and launch of gene therapeutic modalities. The sub-team focusing on analytical ultracentrifugation (AUC) technologies consists of one subject matter expert (SME) and one part-time analyst.
We are looking for a highly motivated scientist (m/f/d) with a specific focus on/ or interest in analytical ultracentrifugation technologies for the testing and characterization of gene therapy vectors.
**Key Responsibilities:**
* Scouting, evaluation, development and implementation of innovative, cutting edge analytical ultracentrifugation technologies and workflows for the analysis and characterization of viral vectors (predominantly rAAV) for gene therapeutic applications
* Driving and advancing the science to characterize and quantify viral vectors with a highly enthusiastic and agile, interdisciplinary team
* Independent, self-organized hands-on execution of experiments: method development, equipment qualification and assay validation under GMP requirements as well as testing
* Contribution to the development and definition of control and testing strategies for gene therapy vectors (e.g. rAAV payload, full/ empty ratio, process related impurities)
* Independent interpretation, evaluation, and documentation of data and the generation of analytical reports in accordance with current regulations
**Who you are:**
* You have a track record and knowledge (theoretical as well as hands-on) in analytical ultracentrifugation technologies such as e.g. MWL-AUC method, operating Optima-AUC, UltraScan, Sedfit software solutions, as well as developing and applying respective IT and data management tools
* You have knowledge in the area of gene therapeutic modalities (AAV, Lentiviruses, etc.).
* You have knowledge and experience with principles of GMP (e.g. data integrity, equipment qualification, assay validation)
* You have a high degree of self-motivation, responsibility, result-orientation and you are an excellent team player
* You are fluent in English and German language skills (written and spoken)
**Advantages:**
* Flexible time management
* 2092 Euro salary per month for a full-time internship > 3 months
* Reduced meal prices in employee canteen
* Fitness center on campus
* Networking opportunities
* Possibility of accommodation in Roche boarding houses or convenient transportation connections to Munich with the Roche shuttle
**Start:**
As of now or according to agreement for a period of 6 months.
**Roche is an Equal Opportunity Employer.**