You will implement advanced LC-MS methods and develop quantitative assays to support clinical trials through sample analysis and data evaluation, while ensuring proper lab operations and mentoring junior staff.
Anforderungen
- •PhD in relevant discipline
- •Hands-on experience in mass spectrometry
- •Expertise in developing MS-based assays
- •Skilled in operating LC-MS systems
- •Strong understanding of protein quantitation techniques
- •Critical thinking and problem-solving skills
- •Proficient in English; German knowledge a plus
Deine Aufgaben
- •Evaluate and implement advanced LC-MS methods.
- •Develop, validate, and implement LC-MS assays.
- •Plan and execute work to support clinical trials.
- •Handle and prepare samples for LC-MS analysis.
- •Conduct data analysis and critical evaluation.
- •Ensure proper operation and maintenance of LC-MS equipment.
- •Contribute to laboratory organization and documentation.
- •Promote achievements through presentations and publications.
- •Train and mentor less experienced staff.
Original Beschreibung
# Postdoc - Biomarker quantitation LC-MS
**The Position**
We are seeking an exceptionally talented postdoc to join our multidisciplinary team of biomarker experts at our largest R&D site in Biberach an der Riß (Germany), where you will have access to state-of-the-art instrumentation.
With your expertise, agility and problem-solving mindset, you will be able to implement advanced LC-MS approaches that will be decisive for quantifying biomarkers and supporting successfully our pipeline.
This position is part time eligible with 80%.
This Position is limited for 2 years.
Note: To make it easier to find our job advertisements, we use the usual designation "Post Doc". Of course, this advertisement is not only addressed to applicants directly after completing their doctorate, but to all qualified candidates
**Tasks & responsibilities**
* In your new role, you will evaluate and implement advanced LC-MS approaches (e.g., micro-LC, column-switching, MS3, immune-capture) to achieve highly sensitive, targeted quantitation of biomarkers.
* Furthermore, you will develop, validate, and implement targeted, quantitative, fit-for-purpose LC-MS assays biomarkers, with a focus on proteins.
* You will plan and execute work to timely support clinical trials and translational studies, including sample handling and preparation, LC-MS analysis, data analysis, critical evaluation, and reporting.
* Moreover, you will ensure proper operation, troubleshooting, and maintenance of LC-MS and laboratory equipment.
* You will contribute to laboratory operation, organization and documentation according to our Quality system.
* In addition, you will promote achievements through presentations and publications (internally and externally).
* You will train and mentor less experienced staff.
**Requirements**
* PhD in analytical chemistry, biochemistry, pharmaceutical sciences, or a related discipline.
* Proven hands-on experience in mass spectrometry (primarily: triple quadrupole; optionally: Orbitrap) and liquid chromatography techniques (RP-LC, HILIC, UHPLC), including sample preparation for proteins and peptides.
* Demonstrated expertise and track record of developing MS-based quantitative assays in biological samples (especially biomarkers), ideally with pharmaceutical or CRO experience and knowledge of applicable guidelines.
* Skilled in operating, troubleshooting, and maintaining LC-MS systems with a proven ability to independently lead complex bioanalytical projects and ensure high performance and data quality through a proactive and innovative mindset.
* Strong understanding of protein quantitation techniques, including sample preparation strategies (like bottom-up proteomics, immunocapture), LC-MS (e.g. PRM, SRM-MS, MS3) as well as utilization of dedicated databases (e.g. UniProtKB, ExPASy, PeptideAtlas), software packages (e.g. Skyline).
* Ability to work independently and team-oriented, with critical thinking, problem-solving attitude with attention to detail and strong organizational skills.
* Proficient in English (spoken and written); German knowledge or willingness to learn is desirable