You focus on developing and optimizing oligonucleotide processes, ensuring efficient resource use and high safety standards while supporting R&D and manufacturing efforts.
Anforderungen
- •Master’s degree in Organic Chemistry preferred
- •Industrial experience in oligonucleotide synthesis
- •Hands-on experience with oligo synthesizers and TFF systems
- •Advanced experience in programming synthesizers
- •Proficiency in liquid chromatography and mass spectrometry
- •Fluency in English
Deine Aufgaben
- •Develop efficient oligonucleotide processes for projects.
- •Optimize synthesis and purification methods in R&D.
- •Generate and document reliable data for development.
- •Investigate diverse synthesis approaches using automated platforms.
- •Apply state-of-the-art technologies in development activities.
- •Utilize laboratory resources to maximize productivity.
- •Uphold high standards of laboratory and process safety.
- •Co-author documentation for process transfer to pilot plants.
- •Consult on troubleshooting during manufacturing campaigns.
Original Beschreibung
# Expert Science & Technology (Oligonucleotide Synthesis)
**Basel (City)** | **Full time**
**Job Description Summary**
Location: Basel, Switzerland
Role Purpose:
Design, plan, perform, interpret and report results of scientific experiments for the preparation and timely delivery of drug substances (DS), drug products (DP), processes and procedures within a multifunctional project team coordinated by a Project Leader. Manage technical lab/plant activities.
**Job Description**
**Your responsibilities include, but are not limited to:**
* Developing efficient and scalable oligonucleotide processes for relevant projects within the Novartis portfolio, across various scales.
* Contributing to the Oligo team by developing and optimizing synthesis and purification methods used in process R&D.
* Generating and documenting reliable data to support oligonucleotide process development.
* Investigating diverse approaches to oligonucleotide synthesis and evaluating their potential using cutting-edge automated platforms.
* Ensuring the application of state-of-the-art technologies in all development activities.
* Utilizing laboratory resources efficiently to maximize productivity.
* Upholding high standards of laboratory and process safety.
* Co-authoring documentation required for process transfer to pilot plants.
* Acting as a consultant for troubleshooting during manufacturing campaigns.
**What you’ll bring to the role:**
* A completed Master’s degree in Organic Chemistry is an advantage.
* Industrial experience with a focus on oligonucleotide synthesis.
* Hands-on experience in operating and maintaining state-of-the-art equipment, including oligo synthesizers, tangential flow filtration (TFF) systems, chromatography units, and lyophilizers.
* Advanced experience in programming methods for synthesizers and chromatography systems.
* Proficiency in common analytical techniques for oligonucleotides, including liquid chromatography (LC) and mass spectrometry (MS).
* Fluency in English.
**Skills Desired**