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Novartis
3d ago

Principal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics(m/w/x)

Basel
Full-timeOn-siteExperienced

Description

In this leadership role, you will drive the scale-up of innovative siRNA therapies by managing a specialized synthesis facility and mentoring a team of scientists to advance the drug pipeline.

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Requirements

  • Ph.D. in Chemistry, oligonucleotide synthesis focus
  • 2–3 years of industry experience
  • Oligonucleotide solid‑phase synthesis and downstream processing
  • Expertise in process development
  • Leadership capabilities and scientific team development
  • Innovation implementation in global team environments
  • Independent problem-solving skills
  • Highly collaborative mindset
  • Effective multi-priority management and objective focus
  • Excellent verbal and written communication skills

Education

Doctoral / PhD

Work Experience

2 - 3 years

Tasks

  • Plan and execute large-scale solid-phase synthesis
  • Purify and analyze chemically modified oligonucleotides
  • Oversee a state-of-the-art synthesis facility
  • Manage capital and consumables budgets efficiently
  • Lead and mentor a specialized team of scientists
  • Support the growing siRNA portfolio at millimole scale
  • Deliver high-quality materials for screening and studies
  • Collaborate with discovery teams in Basel and Cambridge
  • Optimize methodologies for enhanced synthesis efficiency
  • Partner with chemists to scale up new siRNA chemistries
  • Document findings for patent applications and publications
  • Train team members by sharing technical expertise
  • Apply strong problem-solving skills to scientific challenges

Tools & Technologies

Automated synthesizers

Languages

EnglishBusiness Fluent

Benefits

Other Benefits

  • Reasonable accommodation for recruitment
  • Reasonable accommodation for essential functions
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