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NONovartis

Principal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics(m/w/x)

Basel
Full-timeOn-siteExperienced

Large-scale solid-phase synthesis of chemically modified oligonucleotides for siRNA therapies, overseeing a state-of-the-art facility. Ph.D. in Chemistry with oligonucleotide synthesis focus, 2-3 years industry experience, and process development expertise required. Leadership role within a specialized scientific team.

Requirements

  • Ph.D. in Chemistry, oligonucleotide synthesis focus
  • 2–3 years of industry experience
  • Oligonucleotide solid‑phase synthesis and downstream processing
  • Expertise in process development
  • Leadership capabilities and scientific team development
  • Innovation implementation in global team environments
  • Independent problem-solving skills
  • Highly collaborative mindset
  • Effective multi-priority management and objective focus
  • Excellent verbal and written communication skills

Tasks

  • Plan and execute large-scale solid-phase synthesis
  • Purify and analyze chemically modified oligonucleotides
  • Oversee a state-of-the-art synthesis facility
  • Manage capital and consumables budgets efficiently
  • Lead and mentor a specialized team of scientists
  • Support the growing siRNA portfolio at millimole scale
  • Deliver high-quality materials for screening and studies
  • Collaborate with discovery teams in Basel and Cambridge
  • Optimize methodologies for enhanced synthesis efficiency
  • Partner with chemists to scale up new siRNA chemistries
  • Document findings for patent applications and publications
  • Train team members by sharing technical expertise
  • Apply strong problem-solving skills to scientific challenges

Work Experience

  • 2 - 3 years

Education

  • Doctoral / PhD

Languages

  • EnglishBusiness Fluent

Tools & Technologies

  • Automated synthesizers

Benefits

Other Benefits

  • Reasonable accommodation for recruitment
  • Reasonable accommodation for essential functions
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