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NONovartis Pharma AG

Principal Scientist, Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics(m/w/x)

Basel
Full-timeOn-siteExperienced

Overseeing facility operations for mid/large scale siRNA product synthesis and purification, delivering for in vitro and in vivo evaluation. PhD in synthetic chemistry focused on oligonucleotides, with practical solid phase synthesis and downstream processing experience required. Budget management for capital and consumables, leading a team of scientists.

Requirements

  • PhD in synthetic chemistry focused on oligonucleotides
  • Practical experience in oligonucleotide solid phase synthesis and downstream processing
  • Demonstrated leadership abilities
  • Capacity to promote and implement innovative ideas
  • Strong independent problem-solving skills
  • Proven collaborative attitude
  • Proficiency in managing multiple priorities effectively
  • Excellent verbal and written communication abilities

Tasks

  • Oversee the oligonucleotide synthesis facility
  • Manage capital and consumables budgets
  • Lead a team of scientists in oligonucleotide synthesis and purification
  • Deliver high-quality siRNA products for in vitro screening
  • Deliver siRNA products for in vivo evaluation
  • Collaborate with xRNA and oligonucleotide synthesis teams in Basel and Cambridge
  • Provide technical leadership to the scale-up team
  • Optimize methodologies and processes for improved efficiencies
  • Collaborate with synthetic chemists to scale up new siRNA chemistries
  • Facilitate the transition of new chemistries into development
  • Document and communicate results to stakeholders
  • Prepare patent applications and scientific publications
  • Mentor team members by sharing technical expertise

Work Experience

  • 2 - 3 years

Education

  • Doctoral / PhD

Languages

  • EnglishBusiness Fluent
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