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Principal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics(m/w/x)
Large-scale solid-phase synthesis of chemically modified oligonucleotides for siRNA therapies, overseeing a state-of-the-art facility. Ph.D. in Chemistry with oligonucleotide synthesis focus, 2-3 years industry experience, and process development expertise required. Leadership role within a specialized scientific team.
Requirements
- Ph.D. in Chemistry, oligonucleotide synthesis focus
- 2–3 years of industry experience
- Oligonucleotide solid‑phase synthesis and downstream processing
- Expertise in process development
- Leadership capabilities and scientific team development
- Innovation implementation in global team environments
- Independent problem-solving skills
- Highly collaborative mindset
- Effective multi-priority management and objective focus
- Excellent verbal and written communication skills
Tasks
- Plan and execute large-scale solid-phase synthesis
- Purify and analyze chemically modified oligonucleotides
- Oversee a state-of-the-art synthesis facility
- Manage capital and consumables budgets efficiently
- Lead and mentor a specialized team of scientists
- Support the growing siRNA portfolio at millimole scale
- Deliver high-quality materials for screening and studies
- Collaborate with discovery teams in Basel and Cambridge
- Optimize methodologies for enhanced synthesis efficiency
- Partner with chemists to scale up new siRNA chemistries
- Document findings for patent applications and publications
- Train team members by sharing technical expertise
- Apply strong problem-solving skills to scientific challenges
Work Experience
- 2 - 3 years
Education
- Doctoral / PhD
Languages
- English – Business Fluent
Tools & Technologies
- Automated synthesizers
Benefits
Other Benefits
- Reasonable accommodation for recruitment
- Reasonable accommodation for essential functions
Not a perfect match?
- Novartis Pharma AGFull-timeOn-siteExperiencedBasel
- Novartis Pharma AG
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Principal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics(m/w/x)
Large-scale solid-phase synthesis of chemically modified oligonucleotides for siRNA therapies, overseeing a state-of-the-art facility. Ph.D. in Chemistry with oligonucleotide synthesis focus, 2-3 years industry experience, and process development expertise required. Leadership role within a specialized scientific team.
Requirements
- Ph.D. in Chemistry, oligonucleotide synthesis focus
- 2–3 years of industry experience
- Oligonucleotide solid‑phase synthesis and downstream processing
- Expertise in process development
- Leadership capabilities and scientific team development
- Innovation implementation in global team environments
- Independent problem-solving skills
- Highly collaborative mindset
- Effective multi-priority management and objective focus
- Excellent verbal and written communication skills
Tasks
- Plan and execute large-scale solid-phase synthesis
- Purify and analyze chemically modified oligonucleotides
- Oversee a state-of-the-art synthesis facility
- Manage capital and consumables budgets efficiently
- Lead and mentor a specialized team of scientists
- Support the growing siRNA portfolio at millimole scale
- Deliver high-quality materials for screening and studies
- Collaborate with discovery teams in Basel and Cambridge
- Optimize methodologies for enhanced synthesis efficiency
- Partner with chemists to scale up new siRNA chemistries
- Document findings for patent applications and publications
- Train team members by sharing technical expertise
- Apply strong problem-solving skills to scientific challenges
Work Experience
- 2 - 3 years
Education
- Doctoral / PhD
Languages
- English – Business Fluent
Tools & Technologies
- Automated synthesizers
Benefits
Other Benefits
- Reasonable accommodation for recruitment
- Reasonable accommodation for essential functions
About the Company
Novartis
Industry
Pharmaceuticals
Description
Novartis xRNA Therapeutics is developing innovative siRNA therapies to address significant unmet medical needs.
Not a perfect match?
- Novartis Pharma AG
Principal Scientist, Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics(m/w/x)
Full-timeOn-siteExperiencedBasel - Novartis Pharma AG
Senior Scientist – Small Scale Oligonucleotide Synthesis(m/w/x)
Full-timeOn-siteSeniorBasel - Novartis Pharma AG
Senior Scientist - xRNA /sIRNA Discovery(m/w/x)
Full-timeOn-siteSeniorBasel - Novartis Pharma AG
Senior Scientist - xRNA /sIRNA Discovery(m/w/x)
Full-timeOn-siteSeniorBasel - Novartis Pharma AG
Associate Director Science & Technology(m/w/x)
Full-timeOn-siteExperiencedBasel