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GS
GSK
9d ago

Principal Scientist Single Cell TCR Analyst(m/w/x)

Heidelberg
Full-timeOn-siteExperienced
AI/ML

Description

You will bridge the gap between immunology and AI by using deep learning to analyze TCR data, ultimately developing the predictive biomarkers that drive the company's precision immunotherapy programs.

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Requirements

  • PhD in Computational Biology, Bioinformatics, Machine Learning, or related field
  • Extensive experience in single-cell RNA-seq and TCR sequencing analysis
  • Proficiency in Python with deep learning frameworks
  • Strong statistical and machine learning skills
  • Ability to communicate with diverse team members
  • Positive can-do and result-oriented attitude
  • 2+ years of postdoctoral or industry experience
  • Experience with structural biology tools and interaction prediction
  • Excellent leadership and communication skills

Education

Doctoral / PhD

Work Experience

2 years

Tasks

  • Analyze single-cell RNA-seq and paired TCR sequencing data
  • Identify clonotypes and assess repertoire diversity
  • Integrate TCR data with transcriptional phenotypes
  • Build and maintain Python-based analysis pipelines
  • Apply deep learning architectures to predict TCR:pMHC interactions
  • Utilize sequence and structural features in modeling
  • Collaborate with immunologists and AI engineers
  • Translate TCR insights into clinical biomarkers
  • Develop biomarker signatures correlating TCR features with outcomes
  • Support the development of companion diagnostics

Tools & Technologies

SeuratScanpyscRepertoireScirpyPythonPyTorchTensorFlowAlphaFoldmolecular dynamics

Languages

EnglishBusiness Fluent

Benefits

Other Benefits

  • Recruitment process adjustments
Find the original job posting in its most current version here. Nejo automatically captured this job from the website of GSK and processed the information on Nejo with the help of AI for you. Despite careful analysis, some information may be incomplete or inaccurate. Please always verify all details in the original posting! Content and copyrights of the original posting belong to the advertising company.
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