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Principal Scientist for High Throughput Biochemistry(m/w/x)
Designing and developing robust biochemical assays for high-throughput screening. Ph.D. in a life-science discipline and industrial drug discovery experience required. Collaboration across drug discovery teams, strategic project guidance.
Requirements
- Ph.D. in Biochemistry, Biology, Biotechnology, Pharmacology, or related life-science discipline
- Longstanding experience, preferably in industrial drug discovery
- Strong expertise in high-throughput assay development, screening, and compound profiling
- Solid background in biochemical and/or biophysical assay systems
- Sound knowledge of enzymology for molecular pharmacology questions
- Mode-of-action studies knowledge
- Solid understanding of assay robustness and data quality for HTS performance
- Knowledge of relevant screening statistics
- Additional expertise in DNA-Encoded Library (DEL) screening and follow-up workflows is an advantage
- Additional expertise in mass spectrometry-based screening or affinity-selection MS is an advantage
- Additional expertise in Biophysical assays (e.g., SPR, MST, nanoDSF) is an advantage
- Excellent communication and collaboration skills
- Ability to operate effectively in multidisciplinary and matrix environments
- Proven leadership capabilities
- Strong commitment to talent development
- Strong commitment to scientific excellence
- Applications from persons with severe disabilities are warmly welcomed
- Preferential consideration for severely disabled applicants in cases of equal qualifications
Tasks
- Lead high-throughput screening and profiling assays
- Drive scientific excellence and assay innovation
- Collaborate across Drug Discovery Sciences, Therapeutic Areas, and Medicinal Chemistry
- Provide scientific and strategic guidance for project support
- Design and develop robust biochemical assays
- Implement high-throughput technologies for hit finding and compound optimization
- Define and drive screening strategies for chemical starting points
- Select and assess data quality for screening outcomes
- Represent HTB in cross-disciplinary project teams
- Contribute to scientific and technological innovation
- Serve as an expert in biophysical assays (DEL, SPR/DSF, AS-MS, spectral-shift)
- Identify key scientific needs and set priorities
- Jointly define hit-finding and early drug discovery strategies
- Mentor and develop team members
- Foster a culture of scientific rigor and collaboration
- Prioritize workloads with global HTB objectives
Work Experience
- approx. 4 - 6 years
Education
- Doctoral / PhD
Languages
- English – Business Fluent
Tools & Technologies
- SPR
- MST
- nanoDSF
- Home
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- Principal Scientist for High Throughput BiochemistryPrincipal Scientist for High Throughput Biochemistry at B...
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- Home
- Jobs in Germany
- Principal Scientist for High Throughput BiochemistryPrincipal Scientist for High Throughput Biochemistry at B...
Principal Scientist for High Throughput Biochemistry(m/w/x)
Designing and developing robust biochemical assays for high-throughput screening. Ph.D. in a life-science discipline and industrial drug discovery experience required. Collaboration across drug discovery teams, strategic project guidance.
Requirements
- Ph.D. in Biochemistry, Biology, Biotechnology, Pharmacology, or related life-science discipline
- Longstanding experience, preferably in industrial drug discovery
- Strong expertise in high-throughput assay development, screening, and compound profiling
- Solid background in biochemical and/or biophysical assay systems
- Sound knowledge of enzymology for molecular pharmacology questions
- Mode-of-action studies knowledge
- Solid understanding of assay robustness and data quality for HTS performance
- Knowledge of relevant screening statistics
- Additional expertise in DNA-Encoded Library (DEL) screening and follow-up workflows is an advantage
- Additional expertise in mass spectrometry-based screening or affinity-selection MS is an advantage
- Additional expertise in Biophysical assays (e.g., SPR, MST, nanoDSF) is an advantage
- Excellent communication and collaboration skills
- Ability to operate effectively in multidisciplinary and matrix environments
- Proven leadership capabilities
- Strong commitment to talent development
- Strong commitment to scientific excellence
- Applications from persons with severe disabilities are warmly welcomed
- Preferential consideration for severely disabled applicants in cases of equal qualifications
Tasks
- Lead high-throughput screening and profiling assays
- Drive scientific excellence and assay innovation
- Collaborate across Drug Discovery Sciences, Therapeutic Areas, and Medicinal Chemistry
- Provide scientific and strategic guidance for project support
- Design and develop robust biochemical assays
- Implement high-throughput technologies for hit finding and compound optimization
- Define and drive screening strategies for chemical starting points
- Select and assess data quality for screening outcomes
- Represent HTB in cross-disciplinary project teams
- Contribute to scientific and technological innovation
- Serve as an expert in biophysical assays (DEL, SPR/DSF, AS-MS, spectral-shift)
- Identify key scientific needs and set priorities
- Jointly define hit-finding and early drug discovery strategies
- Mentor and develop team members
- Foster a culture of scientific rigor and collaboration
- Prioritize workloads with global HTB objectives
Work Experience
- approx. 4 - 6 years
Education
- Doctoral / PhD
Languages
- English – Business Fluent
Tools & Technologies
- SPR
- MST
- nanoDSF
About the Company
Boehringer Ingelheim
Industry
Pharmaceuticals
Description
The company is focused on delivering lasting value to patients through innovative therapies and early clinical development.
Not a perfect match?
- Boehringer Ingelheim
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Global Program Safety Lead(m/w/x)
Full-timeOn-siteSeniorSeelbach - Boehringer Ingelheim
Internship in Medicinal Chemistry(m/w/x)
Full-timeInternshipOn-siteBiberach - Novartis
Senior Design Engineer(m/w/x)
Full-timeOn-siteSeniorSeelbach - Boehringer Ingelheim
Senior Regulatory Affairs Manager CMC for NBE(m/w/x)
Full-timeOn-siteSeniorIngelheim am Rhein, Biberachfrom USD 80,000 - 100,000 / year