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RORoche

Topic Lead for Structure Elucidation and Mass Spectrometry(m/w/x)

Basel
Full-timeOn-siteSenior

Analytical detective for structure elucidation using LC-MS and GC-MS to solve structural puzzles. Passionate structure elucidation expert with people leadership skills required. Direct impact on developing new medicines.

Requirements

  • Passionate structure elucidation expert with people leadership skills
  • Satisfaction in solving complex structural puzzles
  • Knowledge sharing
  • Thrives in collaborative, high-tech environment
  • Motivated by direct impact on developing new medicines
  • Higher education (Master's or PhD in Chemistry, Biochemistry, or related field)
  • Apprenticeship as laboratory technician
  • Minimum 5 years direct, hands-on experience in structure elucidation
  • Proven leadership skills
  • In-depth experience interpreting high-resolution MS and MS/MS spectra
  • Hands-on skills developing and optimizing chromatographic methods
  • Hands-on skills developing and optimizing mass spectrometry methods
  • Pragmatic, proactive, solution-oriented workstyle
  • Accurate workstyle
  • Balances independent project responsibilities with team collaboration
  • Excellent communication skills
  • Fluency in English
  • Proficiency in German is a plus
  • Keen interest in digital innovation
  • Practical experience with maintenance and troubleshooting of HPLC, GC and MS instrumentation
  • Hands-on experience with 2D-LC-MS
  • Hands-on experience with preparative HPLC
  • Comfortable and experienced working with MS instruments and software from various vendors

Tasks

  • Act as an analytical detective for structure elucidation
  • Use LC-MS and GC-MS systems to solve structural puzzles
  • Identify and characterize unknown impurities
  • Serve as topic lead for structure elucidation
  • Provide subject matter expertise for structure elucidation
  • Maintain oversight on structure elucidation requests
  • Collaborate closely with team members
  • Design and execute lab experiments for structure elucidation
  • Elucidate structures of unknown impurities
  • Analyze impurities from process development
  • Analyze impurities from forced degradation studies
  • Analyze impurities from troubleshooting activities
  • Apply expertise in qualitative LC-HRMS
  • Apply expertise in 2D-LC-HRMS
  • Apply expertise in GC-HRMS
  • Analyze complex drug substances
  • Analyze complex drug products
  • Critically evaluate complex analytical data
  • Interpret complex analytical data
  • Provide clear conclusions in English
  • Provide concise conclusions in English
  • Guide project teams with conclusions
  • Support regulatory filings with conclusions
  • Sense future needs for workflows
  • Identify opportunities to enhance workflows
  • Evaluate new software tools
  • Contribute to team development
  • Act as an Enabler by removing barriers
  • Create a successful work environment
  • Partner with project leads
  • Partner with stakeholders
  • Communicate analytical insights directly
  • Ensure analytical insights are understood
  • Integrate analytical insights into project decisions

Work Experience

  • 5 years

Education

  • Vocational certification

Languages

  • EnglishBusiness Fluent
  • GermanBasic

Tools & Technologies

  • LC-HRMS
  • HPLC
  • GC
  • MS
  • MS/MS
  • 2D-LC-MS
  • GeneData Expressionist
  • ACD/Labs
  • Python
  • JavaScript
Find the original job posting in its most current version here. Nejo automatically captured this job from the website of Roche and processed the information on Nejo with the help of AI for you. Despite careful analysis, some information may be incomplete or inaccurate. Please always verify all details in the original posting! Content and copyrights of the original posting belong to the advertising company.

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