Novartis Pharma AG
Senior Scientist - xRNA /sIRNA Discovery(m/w/x)
Full-timeOn-siteSenior
Basel
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NONovartis Pharma AG
Research Scientist II or Senior Scientist I - Toxicology(m/w/x)
Basel
Full-timeOn-siteSenior
Nejo AI Summary
Conducting in vitro genotoxicity studies for gene therapies and designing cell-based assays to investigate DNA damage. Mammalian cell culture and molecular biology skills required. Data analysis with R or Python, integration site analysis strategies.
Requirements
- Master degree in cellular biology, molecular biology, toxicology or related subject
- Mammalian cell culture experience (primary cells and established cell lines)
- Molecular biology: DNA/RNA extraction, PCR methods, library preparation for sequencing
- Basic programming skills for data analysis (R, Python, etc)
- Strong data interpretation skills and attention to detail
- Independent and collaborative work in cross-functional environment
- Effective communication skills: presenting, manuscript preparation, collaboration
- Proactive, flexible mindset and enthusiasm for non-routine scientific challenges
- Compliance with Good Laboratory Science, Safety, Health and Environment standards
- Experience with gene therapy systems (e.g. AAV, lentiviral vectors, CRISPR/Cas9)
- CRISPR/Cas9 editing
- Experience with DNA damage/repair readouts (e.g. γH2AX, western blot, immunofluorescence, flow cytometry)
- Karyotyping, molecular karyotyping, advanced cytogenetics (FISH, SKY)
- Familiarity with genome safety concepts (integration, clonal expansion, tumorigenicity)
- Exposure to primary human cells (e.g. hepatocytes) and/or advanced in vitro models
- Understanding of regulatory context for nonclinical safety
- Animal Models, Bioinformatics, Collaboration, Communication Skills, Data Analysis, Ethics, Laboratory, Problem Solving, Regulatory Compliance, Research, Risk Assessment, Toxicology
Tasks
- Conduct in vitro genotoxicity studies for gene therapies
- Support mechanistic evaluation of genome integrity
- Generate and analyze experimental data for nonclinical safety
- Contribute to integration site analysis strategies
- Design cell-based assays to investigate DNA damage
- Develop innovative technologies for genetic toxicity testing
- Collaborate with internal and external partners on study design
- Document and communicate results in reports and presentations
- Support regulatory-relevant data interpretation and summaries
- Contribute to safety assessment of diverse therapeutic modalities
Work Experience
- approx. 4 - 6 years
Education
- No education required
Languages
- English – Business Fluent
Tools & Technologies
- R
- Python
- AAV
- lentiviral vectors
- CRISPR/Cas9
- γH2AX
- western blot
- immunofluorescence
- flow cytometry
- Karyotyping
- molecular karyotyping
- FISH
- SKY
Find the original job posting in its most current version here. Nejo automatically captured this job from the website of Novartis Pharma AG and processed the information on Nejo with the help of AI for you. Despite careful analysis, some information may be incomplete or inaccurate. Please always verify all details in the original posting! Content and copyrights of the original posting belong to the advertising company.
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NONovartis Pharma AG
Research Scientist II or Senior Scientist I - Toxicology(m/w/x)
Basel
Full-timeOn-siteSenior
Nejo AI Summary
Conducting in vitro genotoxicity studies for gene therapies and designing cell-based assays to investigate DNA damage. Mammalian cell culture and molecular biology skills required. Data analysis with R or Python, integration site analysis strategies.
Requirements
- Master degree in cellular biology, molecular biology, toxicology or related subject
- Mammalian cell culture experience (primary cells and established cell lines)
- Molecular biology: DNA/RNA extraction, PCR methods, library preparation for sequencing
- Basic programming skills for data analysis (R, Python, etc)
- Strong data interpretation skills and attention to detail
- Independent and collaborative work in cross-functional environment
- Effective communication skills: presenting, manuscript preparation, collaboration
- Proactive, flexible mindset and enthusiasm for non-routine scientific challenges
- Compliance with Good Laboratory Science, Safety, Health and Environment standards
- Experience with gene therapy systems (e.g. AAV, lentiviral vectors, CRISPR/Cas9)
- CRISPR/Cas9 editing
- Experience with DNA damage/repair readouts (e.g. γH2AX, western blot, immunofluorescence, flow cytometry)
- Karyotyping, molecular karyotyping, advanced cytogenetics (FISH, SKY)
- Familiarity with genome safety concepts (integration, clonal expansion, tumorigenicity)
- Exposure to primary human cells (e.g. hepatocytes) and/or advanced in vitro models
- Understanding of regulatory context for nonclinical safety
- Animal Models, Bioinformatics, Collaboration, Communication Skills, Data Analysis, Ethics, Laboratory, Problem Solving, Regulatory Compliance, Research, Risk Assessment, Toxicology
Tasks
- Conduct in vitro genotoxicity studies for gene therapies
- Support mechanistic evaluation of genome integrity
- Generate and analyze experimental data for nonclinical safety
- Contribute to integration site analysis strategies
- Design cell-based assays to investigate DNA damage
- Develop innovative technologies for genetic toxicity testing
- Collaborate with internal and external partners on study design
- Document and communicate results in reports and presentations
- Support regulatory-relevant data interpretation and summaries
- Contribute to safety assessment of diverse therapeutic modalities
Work Experience
- approx. 4 - 6 years
Education
- No education required
Languages
- English – Business Fluent
Tools & Technologies
- R
- Python
- AAV
- lentiviral vectors
- CRISPR/Cas9
- γH2AX
- western blot
- immunofluorescence
- flow cytometry
- Karyotyping
- molecular karyotyping
- FISH
- SKY
Find the original job posting in its most current version here. Nejo automatically captured this job from the website of Novartis Pharma AG and processed the information on Nejo with the help of AI for you. Despite careful analysis, some information may be incomplete or inaccurate. Please always verify all details in the original posting! Content and copyrights of the original posting belong to the advertising company.
Like this job?
BetaYour Career Agent finds similar jobs for you every day.
About the Company
Novartis Pharma AG
Industry
Pharmaceuticals
Description
The company is committed to integrating AI-powered tools into drug discovery to enhance data-driven solutions.
Not a perfect match?
- Novartis Pharma AG
Senior Scientist - xRNA /sIRNA Discovery(m/w/x)
Full-timeOn-siteSeniorBasel - Novartis Pharma AG
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Senior Scientist, Translational Medicine Oncology (Hematology)(m/w/x)
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In-vivo Research Scientist(m/w/x)
Full-timeOn-siteExperiencedBasel