1201 F. Hoffmann-La Roche AG
Post Doctorate Scientist Single Cell Technologies(m/w/x)
Full-timeOn-siteExperienced
Basel
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121201 F. Hoffmann-La Roche AG
Post Doctorate Scientist(m/w/x)
Basel
Full-timeInternshipOn-site
AI/ML
Data Science
Nejo AI Summary
CRISPR-based platform optimization for pre-mRNA splicing modulation, guide-RNA library construction, and large-scale genomics data analysis. Significant hands-on CRISPR functional genomics screening experience and hybrid wet-lab/computational genomics skillset required. Collaboration within a cross-functional Lead Discovery and Oncology team.
Requirements
- PhD in RNA Biology, Molecular Biology, Genomics, or related discipline
- Deep understanding of RNA biology, particularly pre-mRNA splicing regulation
- Significant hands-on experience with CRISPR-based functional genomics screens
- Highly proficient in complex cloning, lentiviral production, mammalian cell culture, and NGS library preparation
- Hybrid skillset in wet-lab research and computational genomics
- Confidence working independently within matrix teams
- Fluency in English with excellent communication and presentation skills
Tasks
- Establish and optimize a CRISPR-based platform for pre-mRNA splicing modulation
- Design and construct complex guide-RNA libraries in pooled and arrayed formats
- Analyze large-scale genomics data to identify and validate screening hits
- Mechanistically characterize top screening hits and elucidate their mechanisms of action
- Collaborate with a cross-functional team in Lead Discovery and Oncology
- Contribute to high-impact publications and generate intellectual property
Education
- Doctoral / PhD
Languages
- English – Business Fluent
Find the original job posting in its most current version here. Nejo automatically captured this job from the website of 1201 F. Hoffmann-La Roche AG and processed the information on Nejo with the help of AI for you. Despite careful analysis, some information may be incomplete or inaccurate. Please always verify all details in the original posting! Content and copyrights of the original posting belong to the advertising company.
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121201 F. Hoffmann-La Roche AG
Post Doctorate Scientist(m/w/x)
Basel
Full-timeInternshipOn-site
AI/ML
Data Science
Nejo AI Summary
CRISPR-based platform optimization for pre-mRNA splicing modulation, guide-RNA library construction, and large-scale genomics data analysis. Significant hands-on CRISPR functional genomics screening experience and hybrid wet-lab/computational genomics skillset required. Collaboration within a cross-functional Lead Discovery and Oncology team.
Requirements
- PhD in RNA Biology, Molecular Biology, Genomics, or related discipline
- Deep understanding of RNA biology, particularly pre-mRNA splicing regulation
- Significant hands-on experience with CRISPR-based functional genomics screens
- Highly proficient in complex cloning, lentiviral production, mammalian cell culture, and NGS library preparation
- Hybrid skillset in wet-lab research and computational genomics
- Confidence working independently within matrix teams
- Fluency in English with excellent communication and presentation skills
Tasks
- Establish and optimize a CRISPR-based platform for pre-mRNA splicing modulation
- Design and construct complex guide-RNA libraries in pooled and arrayed formats
- Analyze large-scale genomics data to identify and validate screening hits
- Mechanistically characterize top screening hits and elucidate their mechanisms of action
- Collaborate with a cross-functional team in Lead Discovery and Oncology
- Contribute to high-impact publications and generate intellectual property
Education
- Doctoral / PhD
Languages
- English – Business Fluent
Find the original job posting in its most current version here. Nejo automatically captured this job from the website of 1201 F. Hoffmann-La Roche AG and processed the information on Nejo with the help of AI for you. Despite careful analysis, some information may be incomplete or inaccurate. Please always verify all details in the original posting! Content and copyrights of the original posting belong to the advertising company.
About the Company
1201 F. Hoffmann-La Roche AG
Industry
Pharmaceuticals
Description
Roche is dedicated to advancing science and ensuring access to healthcare for everyone, with over 100,000 employees globally.
Not a perfect match?
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