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1201 F. Hoffmann-La Roche AG
last mo.

Post Doctorate Scientist(m/w/x)

Basel
Full-timeInternshipOn-site
AI/ML
Data Science

Description

In this role, you will lead the development of a groundbreaking CRISPR-based platform, collaborating with scientists to analyze genomic data and drive innovations in drug discovery, while also contributing to impactful research publications.

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Requirements

  • •PhD in RNA Biology, Molecular Biology, Genomics, or related discipline
  • •Deep understanding of RNA biology, particularly pre-mRNA splicing regulation
  • •Significant hands-on experience with CRISPR-based functional genomics screens
  • •Highly proficient in complex cloning, lentiviral production, mammalian cell culture, and NGS library preparation
  • •Hybrid skillset in wet-lab research and computational genomics
  • •Confidence working independently within matrix teams
  • •Fluency in English with excellent communication and presentation skills

Education

Doctoral / PhD

Tasks

  • •Establish and optimize a CRISPR-based platform for pre-mRNA splicing modulation
  • •Design and construct complex guide-RNA libraries in pooled and arrayed formats
  • •Analyze large-scale genomics data to identify and validate screening hits
  • •Mechanistically characterize top screening hits and elucidate their mechanisms of action
  • •Collaborate with a cross-functional team in Lead Discovery and Oncology
  • •Contribute to high-impact publications and generate intellectual property

Languages

English – Business Fluent

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