Isomorphic Labs
DMPK Lead(m/w/x)
Full-timeWith HomeofficeManagement
Lausanne
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ISIsomorphic Labs
DMPK Lead (PBPK Specialist)(m/w/x)
Lausanne
Full-timeWith Home OfficeManagement
AI/ML
Data Science
Nejo AI Summary
Driving DMPK strategy for AI-driven drug discovery, optimizing computational ADME models. Practical experience setting up automated PBPK workflows required. Mission-driven work at the forefront of AI drug discovery.
Requirements
- PhD in Pharmaceutical Science, Pharmacy, Chemistry, or relevant subject
- 5+ years professional experience as DMPK Lead
- Experience solving DMPK problems in preclinical development
- Track record delivering regulatory-ready FIH packages collaboratively
- Practical experience setting up automated PBPK workflows
- Practical experience using PBPK for preclinical development
- Practical experience developing DMPK and quantitative pharmacology packages
- Experience authoring and reviewing regulatory documents, ideally oncology
- Advanced knowledge of PK and PKPD modelling
- Experience partnering with Preclinical and Clinical teams
- Experience with biologics, peptides, and new modalities
- Good understanding of machine learning techniques
- Familiarity with Python and KNIME
Tasks
- Drive DMPK strategy for drug discovery and development.
- Deliver high-quality clinical candidates.
- Use state-of-the-art computational ADME models.
- Use state-of-the-art AI ADME models.
- Optimize computational and AI ADME models.
- Support business with AI/ML Drug Design Platform teams.
- Collaborate to deliver scientific expertise.
- Collaborate to deliver strategic direction.
- Drive improvements in the AI/ML Platform.
- Apply platform improvements to drug design projects.
- Use PBPK modeling to integrate data.
- Accelerate drug design and preclinical development.
- Define Isomorphic Labs' PBPK strategy.
- Develop fit-for-purpose PBPK models.
- Drive drug design using PBPK models.
- Accelerate preclinical development using PBPK models.
- Design and implement stage-appropriate DMPK strategies.
- Integrate quantitative pharmacology and project strategies.
- Design mechanistic experiments.
- Support project progression with data.
- Integrate DMPK, PD, and toxicological data.
- Extract decision-making information from data.
- Predict dose and safety windows.
- Define Quantitative Pharmacology strategy with Pharmacology Leads.
- Optimize molecule design and formulation with Chemistry Leads.
- Apply physico-chemistry knowledge to design.
- Apply biotransformation knowledge to design.
- Maintain knowledge of state-of-the-art technologies and methods.
- Increase confidence in human PK prediction.
- Author DMPK sections of regulatory documents.
- Embrace a culture of inclusion.
- Champion continuous professional development.
- Optimize use of Isomorphic Labs' datasets.
- Address fundamental DMPK questions.
- Advance the DMPK field.
Work Experience
- 5 years
Education
- Doctoral / PhD
Languages
- English – Business Fluent
Tools & Technologies
- PBPK
- DMPK
- PK
- PKPD modelling
- machine learning techniques
- Python
- KNIME
Find the original job posting in its most current version here. Nejo automatically captured this job from the website of Isomorphic Labs and processed the information on Nejo with the help of AI for you. Despite careful analysis, some information may be incomplete or inaccurate. Please always verify all details in the original posting! Content and copyrights of the original posting belong to the advertising company.
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ISIsomorphic Labs
DMPK Lead (PBPK Specialist)(m/w/x)
Lausanne
Full-timeWith Home OfficeManagement
AI/ML
Data Science
Nejo AI Summary
Driving DMPK strategy for AI-driven drug discovery, optimizing computational ADME models. Practical experience setting up automated PBPK workflows required. Mission-driven work at the forefront of AI drug discovery.
Requirements
- PhD in Pharmaceutical Science, Pharmacy, Chemistry, or relevant subject
- 5+ years professional experience as DMPK Lead
- Experience solving DMPK problems in preclinical development
- Track record delivering regulatory-ready FIH packages collaboratively
- Practical experience setting up automated PBPK workflows
- Practical experience using PBPK for preclinical development
- Practical experience developing DMPK and quantitative pharmacology packages
- Experience authoring and reviewing regulatory documents, ideally oncology
- Advanced knowledge of PK and PKPD modelling
- Experience partnering with Preclinical and Clinical teams
- Experience with biologics, peptides, and new modalities
- Good understanding of machine learning techniques
- Familiarity with Python and KNIME
Tasks
- Drive DMPK strategy for drug discovery and development.
- Deliver high-quality clinical candidates.
- Use state-of-the-art computational ADME models.
- Use state-of-the-art AI ADME models.
- Optimize computational and AI ADME models.
- Support business with AI/ML Drug Design Platform teams.
- Collaborate to deliver scientific expertise.
- Collaborate to deliver strategic direction.
- Drive improvements in the AI/ML Platform.
- Apply platform improvements to drug design projects.
- Use PBPK modeling to integrate data.
- Accelerate drug design and preclinical development.
- Define Isomorphic Labs' PBPK strategy.
- Develop fit-for-purpose PBPK models.
- Drive drug design using PBPK models.
- Accelerate preclinical development using PBPK models.
- Design and implement stage-appropriate DMPK strategies.
- Integrate quantitative pharmacology and project strategies.
- Design mechanistic experiments.
- Support project progression with data.
- Integrate DMPK, PD, and toxicological data.
- Extract decision-making information from data.
- Predict dose and safety windows.
- Define Quantitative Pharmacology strategy with Pharmacology Leads.
- Optimize molecule design and formulation with Chemistry Leads.
- Apply physico-chemistry knowledge to design.
- Apply biotransformation knowledge to design.
- Maintain knowledge of state-of-the-art technologies and methods.
- Increase confidence in human PK prediction.
- Author DMPK sections of regulatory documents.
- Embrace a culture of inclusion.
- Champion continuous professional development.
- Optimize use of Isomorphic Labs' datasets.
- Address fundamental DMPK questions.
- Advance the DMPK field.
Work Experience
- 5 years
Education
- Doctoral / PhD
Languages
- English – Business Fluent
Tools & Technologies
- PBPK
- DMPK
- PK
- PKPD modelling
- machine learning techniques
- Python
- KNIME
Find the original job posting in its most current version here. Nejo automatically captured this job from the website of Isomorphic Labs and processed the information on Nejo with the help of AI for you. Despite careful analysis, some information may be incomplete or inaccurate. Please always verify all details in the original posting! Content and copyrights of the original posting belong to the advertising company.
About the Company
Isomorphic Labs
Industry
Pharmaceuticals
Description
The company is applying frontier AI to unlock deeper scientific insights and accelerate drug discovery.
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