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ISIsomorphic Labs

DMPK Lead(m/w/x)

Lausanne
Full-timeWith Home OfficeManagement
AI/ML
Data Science

Implementing AI-first strategies for drug discovery at biotech firm applying frontier AI, analyzing PD/toxicological data. PhD in Pharmaceutical Science or Chemistry, plus developing DMPK/quantitative pharmacology packages required. Work with frontier AI for deeper scientific insights.

Requirements

  • PhD in Pharmaceutical Science, Pharmacy, Chemistry, or relevant subject
  • 3+ years' professional experience as DMPK Lead
  • Experience developing DMPK and quantitative pharmacology packages
  • Experience partnering with Preclinical and Clinical teams
  • In depth knowledge of biotransformation
  • In depth knowledge of PK modelling
  • Experience with biologics, peptides and new modalities
  • Advanced knowledge of PKPD modelling
  • Good understanding of machine learning techniques
  • Familiarity with Python and KNIME

Tasks

  • Design and implement AI-first DMPK strategies
  • Integrate quantitative pharmacology into project strategies
  • Design screening cascades and mechanistic experiments
  • Analyze DMPK, PD, and toxicological data
  • Predict clinical doses and safety windows
  • Define Quantitative Pharmacology strategies with Pharmacology Leads
  • Leverage company datasets to solve DMPK questions
  • Optimize molecule design with Chemistry Leads
  • Maintain expertise in human PK prediction methods
  • Author DMPK sections for regulatory documents
  • Promote inclusion and continuous professional development

Work Experience

  • 3 years

Education

  • Doctoral / PhD

Languages

  • EnglishBusiness Fluent

Tools & Technologies

  • Python
  • KNIME
  • Machine learning techniques

Benefits

Other Benefits

  • Disability accommodation
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