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121201 F. Hoffmann-La Roche AG

Structure Elucidation Expert with Focus on Mass Spectrometry(m/w/x)

Basel
Full-timeOn-siteSenior

Analyzing unknown impurities in lab experiments using LC-HRMS, 2D-LC-HRMS, and GC-HRMS. 5 years hands-on structure elucidation with LC-HRMS and in-depth HRMS/MS spectra interpretation for small molecules, peptides, or oligonucleotides required. Collaborative work guiding project teams in a global pharmaceutical setting.

Requirements

  • Higher education (Master's or PhD in Chemistry, Biochemistry, or related field) or apprenticeship as a laboratory technician
  • Minimum of 5 years of direct, hands-on experience in structure elucidation using LC-HRMS
  • Proven, in-depth experience in interpreting high-resolution MS and MS/MS spectra for small molecules, peptides, or oligonucleotides
  • Hands-on skills in developing and optimizing chromatographic (HPLC, GC) and mass spectrometry methods
  • Basic NMR experience
  • Pragmatic, proactive, solution-oriented, and accurate workstyle
  • Excellent communication skills and fluency in English and proficiency in German
  • Keen interest in digital innovation with exposure to tools like GeneData Expressionist®, ACD/Labs or programming languages (Python, JavaScript)
  • Practical experience with maintenance and troubleshooting of HPLC, GC and MS instrumentation
  • Comfortable and experienced in working with MS instruments and software from various vendors

Tasks

  • Design and execute lab experiments for structure elucidation
  • Analyze unknown impurities from process development and degradation studies
  • Utilize qualitative LC-HRMS, 2D-LC-HRMS, and GC-HRMS techniques
  • Evaluate and interpret complex analytical data
  • Provide clear conclusions to guide project teams
  • Support regulatory filings with analytical insights
  • Identify opportunities to enhance workflows
  • Evaluate new software tools for analytical improvement
  • Collaborate with project leads and stakeholders
  • Communicate analytical insights for project integration
  • Participate in cross-functional projects
  • Share knowledge and insights with colleagues

Work Experience

  • 5 years

Education

  • Vocational certification

Languages

  • EnglishBusiness Fluent
  • GermanBasic

Tools & Technologies

  • LC-HRMS
  • HPLC
  • GC
  • MS
  • NMR
  • GeneData Expressionist®
  • ACD/Labs
  • Python
  • JavaScript
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