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CSCSL Behring

Senior Scientist Mass Spectrometry(m/w/x)

Bern
Full-timeOn-siteSenior

Biomolecule characterization using LC-MS for rare disease therapies. 3+ years biopharmaceutical industry experience required. Well-being support, training team members on advanced techniques.

Requirements

  • Postgraduate degree (preferably PhD) in biological sciences, biophysics, or analytical chemistry
  • 3+ years biopharmaceutical industry experience in biomolecule characterization by LC-MS
  • Experience in LC-MS method development, optimization, and qualification using QbD principles
  • Advanced expertise in LC-MS bioanalytics for protein/peptide characterization, especially high-resolution MS (e.g., Orbitrap)
  • Strong experience with peptide mapping, intact/subunit mass analysis, and MAM
  • In-depth knowledge of PTM analysis (glycosylation, deamidation, oxidation, C-terminal variants)
  • Expertise in data evaluation, interpretation, and reporting of complex LC-MS datasets
  • Experience with additional bioanalytical workflows, particularly LC separation techniques (RP-LC, SEC, IEX, CE) is a strong plus
  • Hands-on experience and knowledge in instrument operation and maintenance
  • Good understanding of scientific process, including hypothesis development and experimental design (DoE)
  • Strong expertise in biomolecule characterization using LC-MS approaches
  • Advanced technical knowledge of mass spectrometry techniques and analytical assay development
  • Ability to interpret complex analytical datasets and support scientific decision-making
  • Strong scientific problem-solving and troubleshooting skills
  • Ability to work independently and collaboratively in interdisciplinary and cross-functional teams
  • Strong organizational, documentation, and reporting skills
  • Scientific enthusiasm, creativity, and hands-on laboratory mindset
  • Proficient English verbal and written communication skills
  • Ability to provide technical support, guidance, and training to other scientists and team members

Tasks

  • Apply technical background in biomolecule characterization using LC-MS
  • Develop fit-for-purpose analytical assays
  • Direct workflows and provide technical support
  • Train team members on advanced techniques
  • Contribute to translating innovative platforms into automated methods
  • Design and perform MS-based experiments
  • Interpret results to support product characterization
  • Develop and implement novel analytical methods
  • Ensure methods meet quality by design principles
  • Qualify methods according to project and product demands
  • Act as Subject Matter Expert for mass spectrometry
  • Provide scientific leadership and guidance
  • Evaluate and implement new technologies
  • Manage resources effectively
  • Provide feedback to team members
  • Author lab procedures, protocols, and reports
  • Present at internal and external seminars
  • Operate, troubleshoot, and maintain instruments
  • Collaborate with cross-functional teams
  • Support analytical studies and process development
  • Ensure close collaboration with local and global functions

Work Experience

  • 3 years

Education

  • Master's degree

Languages

  • EnglishBusiness Fluent

Tools & Technologies

  • LC-MS
  • Orbitrap
  • RP-LC
  • SEC
  • IEX
  • CE

Benefits

Mental Health Support

  • Well-being support
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