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NONovartis Pharma AG

Senior Expert Science & Technology – Downstream Process Modelling(m/w/x)

Basel
Full-timeOn-siteSenior

Developing downstream process models for biologics, focusing on chromatography and physicochemical principles. Several years of biologics downstream process development experience required. Inclusion support, accommodation for medical conditions.

Requirements

  • MSc, PhD, or equivalent experience in Biotechnology, Chemical Engineering, Biochemistry, or related field
  • Several years of biologics downstream process development experience
  • Demonstrated focus on process modelling
  • Strong, hands-on expertise in chromatography
  • Mechanistic understanding of separation phenomena
  • Proven experience in downstream process modelling
  • Chromatography modelling, parameter estimation, scale-down/scale-up concepts, and integration of multiple unit operations
  • Ability to design and run experiments for model development and validation
  • Strong programming skills in Python
  • Experience building reusable tools, workflows, or applications
  • Familiarity with data analysis and visualization
  • Familiarity with model deployment concepts

Tasks

  • Develop and apply downstream process models for biologics
  • Focus on chromatography and physicochemical principles
  • Extend modelling to other unit operations like filtration and viral inactivation
  • Integrate individual steps into comprehensive DSP models
  • Design and execute laboratory experiments for model development
  • Generate high-quality data for model calibration and validation
  • Support process design, scale-up, and troubleshooting
  • Conduct robustness studies and inform decision-making
  • Implement models using Python
  • Develop user-friendly tools and apps for broader adoption
  • Translate complex results into actionable insights
  • Communicate with multidisciplinary teams and stakeholders
  • Align modelling activities with project objectives
  • Contribute to the global modelling community
  • Share best practices and innovations
  • Prepare scientific documentation and technical reports
  • Deliver regulatory-relevant materials

Work Experience

  • approx. 4 - 6 years

Education

  • Master's degree

Languages

  • EnglishBusiness Fluent

Tools & Technologies

  • Python

Benefits

Other Benefits

  • Reasonable accommodation for medical condition or disability
  • Inclusion support
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