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NONovartis Pharma AG

Principal Scientist - Translational Intestinal Immunology(m/w/x)

Basel
Full-timeOn-siteExperienced

Translational research in inflammatory bowel disease, linking human biology to druggable targets. PhD or MD with 3+ years translational expertise required. Reasonable accommodation for medical condition or disability.

Requirements

  • PhD or MD in Mucosal Immunology, Gastroenterology, Barrier Immunology, or related field
  • At least 3 years translational research expertise in interdisciplinary setting
  • Mastery of immunological/cell biology/molecular biology assays
  • Experience with in vitro human models relevant to IBD and mucosal immunity
  • Ability to conduct experiments using in vitro human systems and biosamples
  • Knowledge of sample-tracking best practices and consent/ethics
  • Experience collaborating with data scientists
  • Ensuring high quality experimental design and reproducibility
  • Proven track record of completing projects on schedule
  • Prior experience mentoring junior researchers
  • Experience contributing to drug discovery programs
  • Experience in in vitro pharmacology or biomarker studies
  • Data Science literacy
  • Confidence interpreting multi-omic outputs and statistical analyses
  • Gastroenterology knowledge
  • Gastrointestinal Disease knowledge
  • Inflammatory Bowel Diseases knowledge

Tasks

  • Design and execute mechanistic experiments
  • Link human disease biology to druggable targets
  • Accelerate preclinical compound development
  • Strengthen understanding of drug modes of action
  • Differentiate novel drugs from standard-of-care treatments
  • Leverage human biosamples for decision-making data
  • Position candidate molecules for clinical trials
  • Test clinical hypotheses for early clinical strategies
  • Partner with early clinical teams for patient stratification
  • Champion data-driven target discovery
  • Collaborate with data scientists and in vivo biology labs
  • Connect quantitative methods to patient heterogeneity and outcomes
  • Drive a culture of collaboration
  • Develop and mentor talent
  • Maintain integrity in research

Work Experience

  • 3 years

Education

  • Bachelor's degree

Languages

  • EnglishBusiness Fluent

Tools & Technologies

  • multi-parametric flow cytometry
  • primary immune cells
  • epithelial cells
  • slice cultures
  • tissue explants

Benefits

Other Benefits

  • Reasonable accommodation for medical condition or disability
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