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121201 F. Hoffmann-La Roche AG

PhD Internship in Neuromuscular Disorders Lab(m/w/x)

Basel
Full-timeInternshipOn-site

Culturing 3D Neuromuscular Junction organoids, performing AAV transductions, and 3D live imaging. PhD/MD program enrollment and complex cell model/organoid culturing experience required. Direct contribution to patient-focused product development.

Requirements

  • Enrollment in a PhD or medical degree program
  • Background in muscle cell biology, neuroscience, or life science
  • Demonstrable experience in culturing complex cell models and/or organoids
  • Experience with live cell imaging techniques
  • Experience in electrophysiology
  • Familiarity with advanced image analysis software
  • Basic molecular biology techniques
  • Proficiency in statistical software for analyzing biological data sets
  • Strong interest in expanding methodological skills using AAV-based technologies
  • Certificate from university for non-EU/EFTA citizens

Tasks

  • Maintain a detailed electronic lab notebook and data records
  • Culture and maintain 3D Neuromuscular Junction organoids
  • Perform viral transductions using recombinant AAVs
  • Conduct 3D live imaging and multielectrode array (MEA)
  • Analyze data
  • Present research findings to project and cross-functional teams
  • Prepare manuscripts
  • Coordinate with internal core facilities such as imaging and genomics
  • Participate in experimental design and scientific strategy meetings

Education

  • Currently in higher educationOR
  • Bachelor's degree

Languages

  • EnglishBusiness Fluent

Tools & Technologies

  • Harmony
  • FIJI/ImageJ
  • R
  • Python
  • GraphPad Prism
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