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RO
Roche
2d ago

DMPK-PD Project Leader(m/w/x)

Basel
Full-timeOn-siteSenior
AI/ML

Description

You will drive the development of transformative medicines by leading DMPK strategies and modeling. Your day-to-day involves translating complex science into safe, effective clinical candidates for patients.

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Requirements

  • •PharmD, PhD in Pharmaceutical Sciences, Pharmacology, Bioengineering, or comparable qualification
  • •Over 5 years industry experience in pharmacokinetic-related field
  • •Expertise in discovery, early PK characterization, distribution, and PKPD
  • •Solid foundation in pharmacology and physiology
  • •Hands-on experience with modeling and simulation
  • •Proficiency applying AI and ML to DMPK strategy
  • •Drive to master Phoenix, Berkeley Madonna, GastroPlus, or SimCyp
  • •Excellent understanding of PK/PD
  • •Strong communication skills
  • •Proven leadership experience
  • •Accountability for defining and delivering outcomes
  • •Ability to transcend organizational boundaries
  • •Inclusive and authentic leadership
  • •Commitment to diversity and high-trust environments

Education

Bachelor's degree
OR
Doctoral / PhD

Work Experience

5 years

Tasks

  • •Lead drug design and optimization strategies
  • •Profile compounds for all DMPK aspects
  • •Validate target biology and translational PKPD concepts
  • •Support early discovery with translational strategies
  • •Evaluate target modulation through biochemical considerations
  • •Execute PKPD and PBPK modeling activities
  • •Predict human dose and regimens
  • •Assess DDI and support lead optimization
  • •Prepare scientific assessments for regulatory submissions
  • •Deliver DMPK information for internal reviews
  • •Implement biomarker and bioanalytical strategies
  • •Collaborate with partners to ensure patient safety
  • •Facilitate data-driven decision-making within project teams
  • •Maintain professional relationships with stakeholders

Tools & Technologies

Artificial Intelligence (AI)Machine Learning (ML)PhoenixBerkeley MadonnaGastroPlusSimCyp

Languages

English – Business Fluent

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