1201 F. Hoffmann-La Roche AG
Clinical Pharmacology Leader(m/w/x)
Full-timeOn-siteManagement
Basel
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Leading drug design and optimization strategies, profiling compounds for DMPK and translational PKPD concepts at a pharmaceutical company. PharmD/PhD in Pharmaceutical Sciences or related field, with hands-on modeling and simulation experience required. Leading cross-functional teams in drug development.
Requirements
- PharmD, PhD in Pharmaceutical Sciences, Pharmacology, Bioengineering, or comparable qualification
- Over 5 years industry experience in pharmacokinetic-related field
- Expertise in discovery, early PK characterization, distribution, and PKPD
- Solid foundation in pharmacology and physiology
- Hands-on experience with modeling and simulation
- Proficiency applying AI and ML to DMPK strategy
- Drive to master Phoenix, Berkeley Madonna, GastroPlus, or SimCyp
- Excellent understanding of PK/PD
- Strong communication skills
- Proven leadership experience
- Accountability for defining and delivering outcomes
- Ability to transcend organizational boundaries
- Inclusive and authentic leadership
- Commitment to diversity and high-trust environments
Tasks
- Lead drug design and optimization strategies
- Profile compounds for all DMPK aspects
- Validate target biology and translational PKPD concepts
- Support early discovery with translational strategies
- Evaluate target modulation through biochemical considerations
- Execute PKPD and PBPK modeling activities
- Predict human dose and regimens
- Assess DDI and support lead optimization
- Prepare scientific assessments for regulatory submissions
- Deliver DMPK information for internal reviews
- Implement biomarker and bioanalytical strategies
- Collaborate with partners to ensure patient safety
- Facilitate data-driven decision-making within project teams
- Maintain professional relationships with stakeholders
Work Experience
- 5 years
Education
- Bachelor's degree
Languages
- English – Business Fluent
Tools & Technologies
- Artificial Intelligence (AI)
- Machine Learning (ML)
- Phoenix
- Berkeley Madonna
- GastroPlus
- SimCyp
Find the original job posting in its most current version here. Nejo automatically captured this job from the website of Roche and processed the information on Nejo with the help of AI for you. Despite careful analysis, some information may be incomplete or inaccurate. Please always verify all details in the original posting! Content and copyrights of the original posting belong to the advertising company.
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Leading drug design and optimization strategies, profiling compounds for DMPK and translational PKPD concepts at a pharmaceutical company. PharmD/PhD in Pharmaceutical Sciences or related field, with hands-on modeling and simulation experience required. Leading cross-functional teams in drug development.
Requirements
- PharmD, PhD in Pharmaceutical Sciences, Pharmacology, Bioengineering, or comparable qualification
- Over 5 years industry experience in pharmacokinetic-related field
- Expertise in discovery, early PK characterization, distribution, and PKPD
- Solid foundation in pharmacology and physiology
- Hands-on experience with modeling and simulation
- Proficiency applying AI and ML to DMPK strategy
- Drive to master Phoenix, Berkeley Madonna, GastroPlus, or SimCyp
- Excellent understanding of PK/PD
- Strong communication skills
- Proven leadership experience
- Accountability for defining and delivering outcomes
- Ability to transcend organizational boundaries
- Inclusive and authentic leadership
- Commitment to diversity and high-trust environments
Tasks
- Lead drug design and optimization strategies
- Profile compounds for all DMPK aspects
- Validate target biology and translational PKPD concepts
- Support early discovery with translational strategies
- Evaluate target modulation through biochemical considerations
- Execute PKPD and PBPK modeling activities
- Predict human dose and regimens
- Assess DDI and support lead optimization
- Prepare scientific assessments for regulatory submissions
- Deliver DMPK information for internal reviews
- Implement biomarker and bioanalytical strategies
- Collaborate with partners to ensure patient safety
- Facilitate data-driven decision-making within project teams
- Maintain professional relationships with stakeholders
Work Experience
- 5 years
Education
- Bachelor's degree
Languages
- English – Business Fluent
Tools & Technologies
- Artificial Intelligence (AI)
- Machine Learning (ML)
- Phoenix
- Berkeley Madonna
- GastroPlus
- SimCyp
Find the original job posting in its most current version here. Nejo automatically captured this job from the website of Roche and processed the information on Nejo with the help of AI for you. Despite careful analysis, some information may be incomplete or inaccurate. Please always verify all details in the original posting! Content and copyrights of the original posting belong to the advertising company.
About the Company
Roche
Industry
Pharmaceuticals
Description
The company is dedicated to advancing science and ensuring access to healthcare for everyone.
Not a perfect match?
- 1201 F. Hoffmann-La Roche AG
Clinical Pharmacology Leader(m/w/x)
Full-timeOn-siteManagementBasel - 1201 F. Hoffmann-La Roche AG
ADME Pharmacokinetic Study Manager(m/w/x)
Full-timeOn-siteExperiencedBasel - 1201 F. Hoffmann-La Roche AG
Scientist / Senior Scientist in Cheminformatics(m/w/x)
Full-timeOn-siteSeniorBasel - 1201 F. Hoffmann-La Roche AG
Project Toxicologist with large molecule experience(m/w/x)
Full-timeOn-siteSeniorBasel - 1201 F. Hoffmann-La Roche AG
Process Modeller Drug Product(m/w/x)
Full-timeOn-siteSeniorBasel