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Principal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics(m/w/x)
Large-scale solid-phase synthesis of chemically modified oligonucleotides for siRNA therapies, overseeing a state-of-the-art facility. Ph.D. in Chemistry with oligonucleotide synthesis focus, 2-3 years industry experience, and process development expertise required. Leadership role within a specialized scientific team.
Requirements
- Ph.D. in Chemistry, oligonucleotide synthesis focus
- 2–3 years of industry experience
- Oligonucleotide solid‑phase synthesis and downstream processing
- Expertise in process development
- Leadership capabilities and scientific team development
- Innovation implementation in global team environments
- Independent problem-solving skills
- Highly collaborative mindset
- Effective multi-priority management and objective focus
- Excellent verbal and written communication skills
Tasks
- Plan and execute large-scale solid-phase synthesis
- Purify and analyze chemically modified oligonucleotides
- Oversee a state-of-the-art synthesis facility
- Manage capital and consumables budgets efficiently
- Lead and mentor a specialized team of scientists
- Support the growing siRNA portfolio at millimole scale
- Deliver high-quality materials for screening and studies
- Collaborate with discovery teams in Basel and Cambridge
- Optimize methodologies for enhanced synthesis efficiency
- Partner with chemists to scale up new siRNA chemistries
- Document findings for patent applications and publications
- Train team members by sharing technical expertise
- Apply strong problem-solving skills to scientific challenges
Work Experience
- 2 - 3 years
Education
- Doctoral / PhD
Languages
- English – Business Fluent
Tools & Technologies
- Automated synthesizers
Benefits
Other Benefits
- Reasonable accommodation for recruitment
- Reasonable accommodation for essential functions
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Principal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics(m/w/x)
Large-scale solid-phase synthesis of chemically modified oligonucleotides for siRNA therapies, overseeing a state-of-the-art facility. Ph.D. in Chemistry with oligonucleotide synthesis focus, 2-3 years industry experience, and process development expertise required. Leadership role within a specialized scientific team.
Requirements
- Ph.D. in Chemistry, oligonucleotide synthesis focus
- 2–3 years of industry experience
- Oligonucleotide solid‑phase synthesis and downstream processing
- Expertise in process development
- Leadership capabilities and scientific team development
- Innovation implementation in global team environments
- Independent problem-solving skills
- Highly collaborative mindset
- Effective multi-priority management and objective focus
- Excellent verbal and written communication skills
Tasks
- Plan and execute large-scale solid-phase synthesis
- Purify and analyze chemically modified oligonucleotides
- Oversee a state-of-the-art synthesis facility
- Manage capital and consumables budgets efficiently
- Lead and mentor a specialized team of scientists
- Support the growing siRNA portfolio at millimole scale
- Deliver high-quality materials for screening and studies
- Collaborate with discovery teams in Basel and Cambridge
- Optimize methodologies for enhanced synthesis efficiency
- Partner with chemists to scale up new siRNA chemistries
- Document findings for patent applications and publications
- Train team members by sharing technical expertise
- Apply strong problem-solving skills to scientific challenges
Work Experience
- 2 - 3 years
Education
- Doctoral / PhD
Languages
- English – Business Fluent
Tools & Technologies
- Automated synthesizers
Benefits
Other Benefits
- Reasonable accommodation for recruitment
- Reasonable accommodation for essential functions
Like this job?
BetaYour Career Agent finds similar jobs for you every day.
About the Company
Novartis
Industry
Pharmaceuticals
Description
Novartis xRNA Therapeutics is developing innovative siRNA therapies to address significant unmet medical needs.
Not a perfect match?
- Novartis Pharma AG
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Senior Scientist - xRNA /sIRNA Discovery(m/w/x)
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