Novartis Pharma AG
Senior Scientist - xRNA /sIRNA Discovery(m/w/x)
Vollzeitnur vor OrtSenior
Basel
Neuer Job?Nejo!
Dein persönlicher KI-Karriere-Agent
NONovartis Pharma AG
Research Scientist II or Senior Scientist I - Toxicology(m/w/x)
Basel
VollzeitVor OrtSenior
Nejo KI-Zusammenfassung
Conducting in vitro genotoxicity studies for gene therapies and designing cell-based assays to investigate DNA damage. Mammalian cell culture and molecular biology skills required. Data analysis with R or Python, integration site analysis strategies.
Anforderungen
- Master degree in cellular biology, molecular biology, toxicology or related subject
- Mammalian cell culture experience (primary cells and established cell lines)
- Molecular biology: DNA/RNA extraction, PCR methods, library preparation for sequencing
- Basic programming skills for data analysis (R, Python, etc)
- Strong data interpretation skills and attention to detail
- Independent and collaborative work in cross-functional environment
- Effective communication skills: presenting, manuscript preparation, collaboration
- Proactive, flexible mindset and enthusiasm for non-routine scientific challenges
- Compliance with Good Laboratory Science, Safety, Health and Environment standards
- Experience with gene therapy systems (e.g. AAV, lentiviral vectors, CRISPR/Cas9)
- CRISPR/Cas9 editing
- Experience with DNA damage/repair readouts (e.g. γH2AX, western blot, immunofluorescence, flow cytometry)
- Karyotyping, molecular karyotyping, advanced cytogenetics (FISH, SKY)
- Familiarity with genome safety concepts (integration, clonal expansion, tumorigenicity)
- Exposure to primary human cells (e.g. hepatocytes) and/or advanced in vitro models
- Understanding of regulatory context for nonclinical safety
- Animal Models, Bioinformatics, Collaboration, Communication Skills, Data Analysis, Ethics, Laboratory, Problem Solving, Regulatory Compliance, Research, Risk Assessment, Toxicology
Aufgaben
- Conduct in vitro genotoxicity studies for gene therapies
- Support mechanistic evaluation of genome integrity
- Generate and analyze experimental data for nonclinical safety
- Contribute to integration site analysis strategies
- Design cell-based assays to investigate DNA damage
- Develop innovative technologies for genetic toxicity testing
- Collaborate with internal and external partners on study design
- Document and communicate results in reports and presentations
- Support regulatory-relevant data interpretation and summaries
- Contribute to safety assessment of diverse therapeutic modalities
Berufserfahrung
- ca. 4 - 6 Jahre
Ausbildung
- Keine Ausbildung erforderlich
Sprachen
- Englisch – verhandlungssicher
Tools & Technologien
- R
- Python
- AAV
- lentiviral vectors
- CRISPR/Cas9
- γH2AX
- western blot
- immunofluorescence
- flow cytometry
- Karyotyping
- molecular karyotyping
- FISH
- SKY
Die Originalanzeige dieses Stellenangebotes in der aktuellsten Version findest du hier. Nejo hat diesen Job automatisch von der Website des Unternehmens Novartis Pharma AG erfasst und die Informationen auf Nejo mit Hilfe von KI für dich aufbereitet. Trotz sorgfältiger Analyse können einzelne Informationen unvollständig oder ungenau sein. Bitte prüfe immer alle Angaben in der Originalanzeige! Inhalte und Urheberrechte der Originalanzeige liegen beim ausschreibenden Unternehmen.
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NONovartis Pharma AG
Research Scientist II or Senior Scientist I - Toxicology(m/w/x)
Basel
VollzeitVor OrtSenior
Nejo KI-Zusammenfassung
Conducting in vitro genotoxicity studies for gene therapies and designing cell-based assays to investigate DNA damage. Mammalian cell culture and molecular biology skills required. Data analysis with R or Python, integration site analysis strategies.
Anforderungen
- Master degree in cellular biology, molecular biology, toxicology or related subject
- Mammalian cell culture experience (primary cells and established cell lines)
- Molecular biology: DNA/RNA extraction, PCR methods, library preparation for sequencing
- Basic programming skills for data analysis (R, Python, etc)
- Strong data interpretation skills and attention to detail
- Independent and collaborative work in cross-functional environment
- Effective communication skills: presenting, manuscript preparation, collaboration
- Proactive, flexible mindset and enthusiasm for non-routine scientific challenges
- Compliance with Good Laboratory Science, Safety, Health and Environment standards
- Experience with gene therapy systems (e.g. AAV, lentiviral vectors, CRISPR/Cas9)
- CRISPR/Cas9 editing
- Experience with DNA damage/repair readouts (e.g. γH2AX, western blot, immunofluorescence, flow cytometry)
- Karyotyping, molecular karyotyping, advanced cytogenetics (FISH, SKY)
- Familiarity with genome safety concepts (integration, clonal expansion, tumorigenicity)
- Exposure to primary human cells (e.g. hepatocytes) and/or advanced in vitro models
- Understanding of regulatory context for nonclinical safety
- Animal Models, Bioinformatics, Collaboration, Communication Skills, Data Analysis, Ethics, Laboratory, Problem Solving, Regulatory Compliance, Research, Risk Assessment, Toxicology
Aufgaben
- Conduct in vitro genotoxicity studies for gene therapies
- Support mechanistic evaluation of genome integrity
- Generate and analyze experimental data for nonclinical safety
- Contribute to integration site analysis strategies
- Design cell-based assays to investigate DNA damage
- Develop innovative technologies for genetic toxicity testing
- Collaborate with internal and external partners on study design
- Document and communicate results in reports and presentations
- Support regulatory-relevant data interpretation and summaries
- Contribute to safety assessment of diverse therapeutic modalities
Berufserfahrung
- ca. 4 - 6 Jahre
Ausbildung
- Keine Ausbildung erforderlich
Sprachen
- Englisch – verhandlungssicher
Tools & Technologien
- R
- Python
- AAV
- lentiviral vectors
- CRISPR/Cas9
- γH2AX
- western blot
- immunofluorescence
- flow cytometry
- Karyotyping
- molecular karyotyping
- FISH
- SKY
Die Originalanzeige dieses Stellenangebotes in der aktuellsten Version findest du hier. Nejo hat diesen Job automatisch von der Website des Unternehmens Novartis Pharma AG erfasst und die Informationen auf Nejo mit Hilfe von KI für dich aufbereitet. Trotz sorgfältiger Analyse können einzelne Informationen unvollständig oder ungenau sein. Bitte prüfe immer alle Angaben in der Originalanzeige! Inhalte und Urheberrechte der Originalanzeige liegen beim ausschreibenden Unternehmen.
Gefällt dir diese Stelle?
BetaDein Career Agent findet täglich ähnliche Jobs für dich.
Über das Unternehmen
Novartis Pharma AG
Branche
Pharmaceuticals
Beschreibung
The company is committed to integrating AI-powered tools into drug discovery to enhance data-driven solutions.
Noch nicht perfekt?
- Novartis Pharma AG
Senior Scientist - xRNA /sIRNA Discovery(m/w/x)
Vollzeitnur vor OrtSeniorBasel - Novartis Pharma AG
Senior Scientist - xRNA /sIRNA Discovery(m/w/x)
Vollzeitnur vor OrtSeniorBasel - 1201 F. Hoffmann-La Roche AG
Project Toxicologist with large molecule experience(m/w/x)
Vollzeitnur vor OrtSeniorBasel - Roche
Senior Scientist, Translational Medicine Oncology (Hematology)(m/w/x)
Vollzeitnur vor OrtSeniorBasel - Novartis
In-vivo Research Scientist(m/w/x)
Vollzeitnur vor OrtBerufserfahrenBasel