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Post Doctorate Scientist(m/w/x)
CRISPR-based platform optimization for pre-mRNA splicing modulation, guide-RNA library construction, and large-scale genomics data analysis. Significant hands-on CRISPR functional genomics screening experience and hybrid wet-lab/computational genomics skillset required. Collaboration within a cross-functional Lead Discovery and Oncology team.
Anforderungen
- PhD in RNA Biology, Molecular Biology, Genomics, or related discipline
- Deep understanding of RNA biology, particularly pre-mRNA splicing regulation
- Significant hands-on experience with CRISPR-based functional genomics screens
- Highly proficient in complex cloning, lentiviral production, mammalian cell culture, and NGS library preparation
- Hybrid skillset in wet-lab research and computational genomics
- Confidence working independently within matrix teams
- Fluency in English with excellent communication and presentation skills
Aufgaben
- Establish and optimize a CRISPR-based platform for pre-mRNA splicing modulation
- Design and construct complex guide-RNA libraries in pooled and arrayed formats
- Analyze large-scale genomics data to identify and validate screening hits
- Mechanistically characterize top screening hits and elucidate their mechanisms of action
- Collaborate with a cross-functional team in Lead Discovery and Oncology
- Contribute to high-impact publications and generate intellectual property
Ausbildung
- Doktor / Ph.D.
Sprachen
- Englisch – verhandlungssicher
Noch nicht perfekt?
- 1201 F. Hoffmann-La Roche AGVollzeitnur vor OrtBerufserfahrenBasel
- Roche
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Post Doctorate Scientist(m/w/x)
CRISPR-based platform optimization for pre-mRNA splicing modulation, guide-RNA library construction, and large-scale genomics data analysis. Significant hands-on CRISPR functional genomics screening experience and hybrid wet-lab/computational genomics skillset required. Collaboration within a cross-functional Lead Discovery and Oncology team.
Anforderungen
- PhD in RNA Biology, Molecular Biology, Genomics, or related discipline
- Deep understanding of RNA biology, particularly pre-mRNA splicing regulation
- Significant hands-on experience with CRISPR-based functional genomics screens
- Highly proficient in complex cloning, lentiviral production, mammalian cell culture, and NGS library preparation
- Hybrid skillset in wet-lab research and computational genomics
- Confidence working independently within matrix teams
- Fluency in English with excellent communication and presentation skills
Aufgaben
- Establish and optimize a CRISPR-based platform for pre-mRNA splicing modulation
- Design and construct complex guide-RNA libraries in pooled and arrayed formats
- Analyze large-scale genomics data to identify and validate screening hits
- Mechanistically characterize top screening hits and elucidate their mechanisms of action
- Collaborate with a cross-functional team in Lead Discovery and Oncology
- Contribute to high-impact publications and generate intellectual property
Ausbildung
- Doktor / Ph.D.
Sprachen
- Englisch – verhandlungssicher
Über das Unternehmen
1201 F. Hoffmann-La Roche AG
Branche
Pharmaceuticals
Beschreibung
Roche is dedicated to advancing science and ensuring access to healthcare for everyone, with over 100,000 employees globally.
Noch nicht perfekt?
- 1201 F. Hoffmann-La Roche AG
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