Isomorphic Labs
DMPK Lead(m/w/x)
Vollzeitmit HomeofficeManagement
Lausanne
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ISIsomorphic Labs
DMPK Lead (PBPK Specialist)(m/w/x)
Lausanne
Vollzeitmit HomeofficeManagement
AI/ML
Data Science
Nejo KI-Zusammenfassung
Driving DMPK strategy for AI-driven drug discovery, optimizing computational ADME models. Practical experience setting up automated PBPK workflows required. Mission-driven work at the forefront of AI drug discovery.
Anforderungen
- PhD in Pharmaceutical Science, Pharmacy, Chemistry, or relevant subject
- 5+ years professional experience as DMPK Lead
- Experience solving DMPK problems in preclinical development
- Track record delivering regulatory-ready FIH packages collaboratively
- Practical experience setting up automated PBPK workflows
- Practical experience using PBPK for preclinical development
- Practical experience developing DMPK and quantitative pharmacology packages
- Experience authoring and reviewing regulatory documents, ideally oncology
- Advanced knowledge of PK and PKPD modelling
- Experience partnering with Preclinical and Clinical teams
- Experience with biologics, peptides, and new modalities
- Good understanding of machine learning techniques
- Familiarity with Python and KNIME
Aufgaben
- Drive DMPK strategy for drug discovery and development.
- Deliver high-quality clinical candidates.
- Use state-of-the-art computational ADME models.
- Use state-of-the-art AI ADME models.
- Optimize computational and AI ADME models.
- Support business with AI/ML Drug Design Platform teams.
- Collaborate to deliver scientific expertise.
- Collaborate to deliver strategic direction.
- Drive improvements in the AI/ML Platform.
- Apply platform improvements to drug design projects.
- Use PBPK modeling to integrate data.
- Accelerate drug design and preclinical development.
- Define Isomorphic Labs' PBPK strategy.
- Develop fit-for-purpose PBPK models.
- Drive drug design using PBPK models.
- Accelerate preclinical development using PBPK models.
- Design and implement stage-appropriate DMPK strategies.
- Integrate quantitative pharmacology and project strategies.
- Design mechanistic experiments.
- Support project progression with data.
- Integrate DMPK, PD, and toxicological data.
- Extract decision-making information from data.
- Predict dose and safety windows.
- Define Quantitative Pharmacology strategy with Pharmacology Leads.
- Optimize molecule design and formulation with Chemistry Leads.
- Apply physico-chemistry knowledge to design.
- Apply biotransformation knowledge to design.
- Maintain knowledge of state-of-the-art technologies and methods.
- Increase confidence in human PK prediction.
- Author DMPK sections of regulatory documents.
- Embrace a culture of inclusion.
- Champion continuous professional development.
- Optimize use of Isomorphic Labs' datasets.
- Address fundamental DMPK questions.
- Advance the DMPK field.
Berufserfahrung
- 5 Jahre
Ausbildung
- Doktor / Ph.D.
Sprachen
- Englisch – verhandlungssicher
Tools & Technologien
- PBPK
- DMPK
- PK
- PKPD modelling
- machine learning techniques
- Python
- KNIME
Die Originalanzeige dieses Stellenangebotes in der aktuellsten Version findest du hier. Nejo hat diesen Job automatisch von der Website des Unternehmens Isomorphic Labs erfasst und die Informationen auf Nejo mit Hilfe von KI für dich aufbereitet. Trotz sorgfältiger Analyse können einzelne Informationen unvollständig oder ungenau sein. Bitte prüfe immer alle Angaben in der Originalanzeige! Inhalte und Urheberrechte der Originalanzeige liegen beim ausschreibenden Unternehmen.
Noch nicht perfekt?
- Isomorphic Labs
PKPD Modelling Lead(m/w/x)
Vollzeitmit HomeofficeManagementLausanne - Isomorphic Labs
Computational Drug Designer(m/w/x)
Vollzeitmit HomeofficeSeniorLausanne - Isomorphic Labs
Research Scientist (Machine Learning)(m/w/x)
Vollzeitmit HomeofficeManagementLausanne - Isomorphic Labs
Software Engineer, Full Stack(m/w/x)
Vollzeitmit HomeofficeSeniorLausanne
ISIsomorphic Labs
DMPK Lead (PBPK Specialist)(m/w/x)
Lausanne
Vollzeitmit HomeofficeManagement
AI/ML
Data Science
Nejo KI-Zusammenfassung
Driving DMPK strategy for AI-driven drug discovery, optimizing computational ADME models. Practical experience setting up automated PBPK workflows required. Mission-driven work at the forefront of AI drug discovery.
Anforderungen
- PhD in Pharmaceutical Science, Pharmacy, Chemistry, or relevant subject
- 5+ years professional experience as DMPK Lead
- Experience solving DMPK problems in preclinical development
- Track record delivering regulatory-ready FIH packages collaboratively
- Practical experience setting up automated PBPK workflows
- Practical experience using PBPK for preclinical development
- Practical experience developing DMPK and quantitative pharmacology packages
- Experience authoring and reviewing regulatory documents, ideally oncology
- Advanced knowledge of PK and PKPD modelling
- Experience partnering with Preclinical and Clinical teams
- Experience with biologics, peptides, and new modalities
- Good understanding of machine learning techniques
- Familiarity with Python and KNIME
Aufgaben
- Drive DMPK strategy for drug discovery and development.
- Deliver high-quality clinical candidates.
- Use state-of-the-art computational ADME models.
- Use state-of-the-art AI ADME models.
- Optimize computational and AI ADME models.
- Support business with AI/ML Drug Design Platform teams.
- Collaborate to deliver scientific expertise.
- Collaborate to deliver strategic direction.
- Drive improvements in the AI/ML Platform.
- Apply platform improvements to drug design projects.
- Use PBPK modeling to integrate data.
- Accelerate drug design and preclinical development.
- Define Isomorphic Labs' PBPK strategy.
- Develop fit-for-purpose PBPK models.
- Drive drug design using PBPK models.
- Accelerate preclinical development using PBPK models.
- Design and implement stage-appropriate DMPK strategies.
- Integrate quantitative pharmacology and project strategies.
- Design mechanistic experiments.
- Support project progression with data.
- Integrate DMPK, PD, and toxicological data.
- Extract decision-making information from data.
- Predict dose and safety windows.
- Define Quantitative Pharmacology strategy with Pharmacology Leads.
- Optimize molecule design and formulation with Chemistry Leads.
- Apply physico-chemistry knowledge to design.
- Apply biotransformation knowledge to design.
- Maintain knowledge of state-of-the-art technologies and methods.
- Increase confidence in human PK prediction.
- Author DMPK sections of regulatory documents.
- Embrace a culture of inclusion.
- Champion continuous professional development.
- Optimize use of Isomorphic Labs' datasets.
- Address fundamental DMPK questions.
- Advance the DMPK field.
Berufserfahrung
- 5 Jahre
Ausbildung
- Doktor / Ph.D.
Sprachen
- Englisch – verhandlungssicher
Tools & Technologien
- PBPK
- DMPK
- PK
- PKPD modelling
- machine learning techniques
- Python
- KNIME
Die Originalanzeige dieses Stellenangebotes in der aktuellsten Version findest du hier. Nejo hat diesen Job automatisch von der Website des Unternehmens Isomorphic Labs erfasst und die Informationen auf Nejo mit Hilfe von KI für dich aufbereitet. Trotz sorgfältiger Analyse können einzelne Informationen unvollständig oder ungenau sein. Bitte prüfe immer alle Angaben in der Originalanzeige! Inhalte und Urheberrechte der Originalanzeige liegen beim ausschreibenden Unternehmen.
Über das Unternehmen
Isomorphic Labs
Branche
Pharmaceuticals
Beschreibung
The company is applying frontier AI to unlock deeper scientific insights and accelerate drug discovery.
Noch nicht perfekt?
- Isomorphic Labs
DMPK Lead(m/w/x)
Vollzeitmit HomeofficeManagementLausanne - Isomorphic Labs
PKPD Modelling Lead(m/w/x)
Vollzeitmit HomeofficeManagementLausanne - Isomorphic Labs
Computational Drug Designer(m/w/x)
Vollzeitmit HomeofficeSeniorLausanne - Isomorphic Labs
Research Scientist (Machine Learning)(m/w/x)
Vollzeitmit HomeofficeManagementLausanne - Isomorphic Labs
Software Engineer, Full Stack(m/w/x)
Vollzeitmit HomeofficeSeniorLausanne