Novartis Pharma AG
Translational Medicine Academy fellow for Pharmacokinetics Sciences Modeling & Simulaton(m/w/x)
Vollzeitnur vor OrtKeine Angabe
Basel
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NONovartis Pharma AG
Translational Medicine Academy fellow for Pharmacokinetics Sciences Modeling & Simulaton(m/w/x)
Basel
VollzeitVor Ort
Nejo KI-Zusammenfassung
Developing PK/PD modeling frameworks linking drug exposure to immune cell kinetics. PhD in quantitative sciences and mechanistic modeling experience required. Diverse, global environment with mentorship.
Anforderungen
- PhD in quantitative pharmacology/pharmacometrics, bioengineering, systems biology, applied mathematics, biostatistics, computational biology, or related discipline
- Hands-on experience building and evaluating mechanistic models (ODE/PDE, compartmental, systems pharmacology, PK/PD)
- Programming proficiency in Python, R, MATLAB SimBiology, or similar; reproducible, modular, well-documented code
- Experience with biological datasets (preclinical/clinical): cleaning, visualization, model fitting, interpretation
- Strong communication and collaboration skills; translating quantitative findings into biological implications
- Background in immunology, particularly B-cell biology, lymphoid tissue organization, or immune cell trafficking
- Experience modeling biologics and/or cell therapies (target engagement, cell-killing dynamics)
- Familiarity with PBPK or multi-compartment modeling of immune-cell dynamics in cell-based and T-cell therapies (CAR-T, T-cell engaging antibodies)
- Familiarity with PBPK concepts and software (mrgsolve, nlmixr2, NONMEM, Monolix, SimBiology, Stan, or comparable)
- Coding portfolio related to mechanistic modelling or systems biology
- Eligibility to work in Switzerland
Aufgaben
- Develop physiology-based PK/PD modeling framework
- Link drug exposure to B-cell and plasma cell kinetics
- Integrate translational evidence from in vitro, in vivo, and early clinical data
- Estimate parameters and quantify uncertainty
- Connect tissue depletion kinetics to immune-reset biomarkers
- Inform decision-making for B-cell depleting modalities
- Communicate results through presentations, reports, and manuscripts
- Partner with immunology, translational, and modeling stakeholders
- Own end-to-end, production-ready modeling platform
- Expand expertise in quantitative pharmacology and immunology
- Inform dose and schedule optimization for B-cell depleting therapies
- Experience impact of translational modeling in industrial drug development
Ausbildung
- Doktor / Ph.D.
Sprachen
- Englisch – verhandlungssicher
Tools & Technologien
- Python
- R
- MATLAB SimBiology
- mrgsolve
- nlmixr2
- NONMEM
- Monolix
- SimBiology
- Stan
Benefits
Mentoring & Coaching
- Training and mentorship
Weiterbildungsangebote
- Empowerment to learn
Lockere Unternehmenskultur
- Diverse, multicultural, global and inclusive environment
Sonstige Vorteile
- Reasonable accommodation for medical condition or disability
Die Originalanzeige dieses Stellenangebotes in der aktuellsten Version findest du hier. Nejo hat diesen Job automatisch von der Website des Unternehmens Novartis Pharma AG erfasst und die Informationen auf Nejo mit Hilfe von KI für dich aufbereitet. Trotz sorgfältiger Analyse können einzelne Informationen unvollständig oder ungenau sein. Bitte prüfe immer alle Angaben in der Originalanzeige! Inhalte und Urheberrechte der Originalanzeige liegen beim ausschreibenden Unternehmen.
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NONovartis Pharma AG
Translational Medicine Academy fellow for Pharmacokinetics Sciences Modeling & Simulaton(m/w/x)
Basel
VollzeitVor Ort
Nejo KI-Zusammenfassung
Developing PK/PD modeling frameworks linking drug exposure to immune cell kinetics. PhD in quantitative sciences and mechanistic modeling experience required. Diverse, global environment with mentorship.
Anforderungen
- PhD in quantitative pharmacology/pharmacometrics, bioengineering, systems biology, applied mathematics, biostatistics, computational biology, or related discipline
- Hands-on experience building and evaluating mechanistic models (ODE/PDE, compartmental, systems pharmacology, PK/PD)
- Programming proficiency in Python, R, MATLAB SimBiology, or similar; reproducible, modular, well-documented code
- Experience with biological datasets (preclinical/clinical): cleaning, visualization, model fitting, interpretation
- Strong communication and collaboration skills; translating quantitative findings into biological implications
- Background in immunology, particularly B-cell biology, lymphoid tissue organization, or immune cell trafficking
- Experience modeling biologics and/or cell therapies (target engagement, cell-killing dynamics)
- Familiarity with PBPK or multi-compartment modeling of immune-cell dynamics in cell-based and T-cell therapies (CAR-T, T-cell engaging antibodies)
- Familiarity with PBPK concepts and software (mrgsolve, nlmixr2, NONMEM, Monolix, SimBiology, Stan, or comparable)
- Coding portfolio related to mechanistic modelling or systems biology
- Eligibility to work in Switzerland
Aufgaben
- Develop physiology-based PK/PD modeling framework
- Link drug exposure to B-cell and plasma cell kinetics
- Integrate translational evidence from in vitro, in vivo, and early clinical data
- Estimate parameters and quantify uncertainty
- Connect tissue depletion kinetics to immune-reset biomarkers
- Inform decision-making for B-cell depleting modalities
- Communicate results through presentations, reports, and manuscripts
- Partner with immunology, translational, and modeling stakeholders
- Own end-to-end, production-ready modeling platform
- Expand expertise in quantitative pharmacology and immunology
- Inform dose and schedule optimization for B-cell depleting therapies
- Experience impact of translational modeling in industrial drug development
Ausbildung
- Doktor / Ph.D.
Sprachen
- Englisch – verhandlungssicher
Tools & Technologien
- Python
- R
- MATLAB SimBiology
- mrgsolve
- nlmixr2
- NONMEM
- Monolix
- SimBiology
- Stan
Benefits
Mentoring & Coaching
- Training and mentorship
Weiterbildungsangebote
- Empowerment to learn
Lockere Unternehmenskultur
- Diverse, multicultural, global and inclusive environment
Sonstige Vorteile
- Reasonable accommodation for medical condition or disability
Die Originalanzeige dieses Stellenangebotes in der aktuellsten Version findest du hier. Nejo hat diesen Job automatisch von der Website des Unternehmens Novartis Pharma AG erfasst und die Informationen auf Nejo mit Hilfe von KI für dich aufbereitet. Trotz sorgfältiger Analyse können einzelne Informationen unvollständig oder ungenau sein. Bitte prüfe immer alle Angaben in der Originalanzeige! Inhalte und Urheberrechte der Originalanzeige liegen beim ausschreibenden Unternehmen.
Gefällt dir diese Stelle?
BetaDein Career Agent findet täglich ähnliche Jobs für dich.
Über das Unternehmen
Novartis Pharma AG
Branche
Pharmaceuticals
Beschreibung
The company is committed to integrating AI-powered tools into drug discovery to enhance data-driven solutions.
Noch nicht perfekt?
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