Postdoctoral Researcher in CNS Biology/Pharmacology(m/w/x)

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Designing and performing experiments with iPSC-derived neuronal co-cultures for CNS drug discovery. Hands-on experience with multi-electrode arrays for hiPSC-derived neurons required. Work in a biopharmaceutical company focused on innovative medicines.

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Anforderungen

PhD degree in neuroscience or related areas
Proven track record with hiPSC derived neuronal co-cultures
Hands-on experience with multi-electrode arrays for hiPSC-derived neurons
Practical knowledge of in-vitro and in-vivo autism models (advantageous)
Wet lab experience with molecular biology tools (e.g. CRISPR) (advantageous)
Hands-on experience with rodent handling and pharmacology techniques
Solid knowledge of autism spectrum disorders neurobiology
Understanding of ion channels, GPCRs, neuroscience drug discovery, electrophysiology, pharmacology
Self-starter with strong problem-solving skills
Enthusiasm, flexibility, and ability to work in diverse environment
Fluency in English (verbal and written)
Active LTK license for Switzerland (or FELASA equivalent)

Aufgaben

Design, perform, analyze, and interpret experiments in iPSC-derived neuronal co-cultures
Characterize innovative therapeutic agents for CNS drug discovery
Set up and optimize electrophysiology assays of neuronal cocultures
Set up and optimize omics assays of neuronal cocultures
Set up and optimize biochemical assays of neuronal cocultures
Set up and optimize immunocytochemistry assays of neuronal cocultures
Perform mechanism-of-action studies
Introduce disease-causing mutations into iPSC cells using CRISPR
Generate and characterize co-culture-based disease models
Design, perform, analyze, and interpret experiments in rodent CNS disease models
Set up autism-relevant behavioral pharmacology assays
Plan experiments efficiently
Analyze experiments in detail
Document experiments accurately
Present results in a multidisciplinary company environment
Prepare results for publication in peer-reviewed journals
Experimentally test computational models with scientific computing group
Refine computational models with scientific computing group
Evaluate application opportunities for CNS drug discovery
Interact with biologists, pharmacologists, chemists, and computer scientists
Drive innovation in drug discovery projects
Advance drug discovery projects

Ausbildung

Doktor / Ph.D.

Sprachen

Englisch – fließend

Tools & Technologien

hiPSCmulti-electrode arraysCRISPRelectrophysiologypharmacology

Von Nejo automatisch aufbereitet

Nejo hat diesen Job automatisch von der Website des Unternehmens Idorsia erfasst und die Informationen auf Nejo mit Hilfe von KI für dich aufbereitet. Trotz sorgfältiger Analyse können einzelne Informationen unvollständig oder ungenau sein. Bitte prüfe immer alle Angaben in der Originalanzeige! Inhalte und Urheberrechte der Originalanzeige liegen beim ausschreibenden Unternehmen.

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Über das Unternehmen

PharmaceuticalsBasel

The company is a high-potential biopharmaceutical company, specialized in the discovery, development and commercialization of innovative small molecules.

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