F. Hoffmann-La Roche AG
Post Doctoral Scientist (IHB) - Computational Immunology(m/w/x)
Full-timeOn-siteExperienced
Basel
New Job?Nejo!
Your personal AI career agent
RORoche
Post Doctorate Scientist (IHB) - In Vitro Modeling Adaptive Immunologist(m/w/x)
Basel
Full-timeOn-siteExperienced
Nejo AI Summary
Designing in vitro models for adaptive immune responses in human neuroinflammation, including MS and Alzheimer's. Deep expertise in adaptive immune biology and hands-on flow cytometry required. Multi-omic dataset generation, cell sorting, and publications track record.
Requirements
- Ph.D. in Immunology, Neuroimmunology/Neuroinflammation, Bioengineering, or related field
- Doctoral studies completed within last four years
- Strong track record of productivity (publications)
- Deep expertise in adaptive immune biology (T-/B-cell biology)
- Strong hands-on flow cytometry and cell sorting experience
- Experience with primary human cells and/or tissue samples
- Experience establishing/working with in vitro model systems
- Experience generating multi-omic datasets (single-cell RNA-seq, immune profiling)
- Interest in downstream data analysis collaboration
- Strong interest in human immunology and neuroinflammation
- Ability to work effectively in collaborative environment
- Strong communication skills
- Professional fluency in English
- Research experience in neuroinflammation (MS, AD)
- Familiarity with CNS and/or meningeal biology
- Experience with stromal cell biology and/or tissue niche interactions
- Experience studying/modeling tertiary lymphoid structures (TLS)
- Experience developing advanced in vitro systems (co-culture, organoids, ex vivo)
- Experience with advanced immune profiling (spectral flow cytometry)
- Exposure to spatial biology workflows or sample preparation
- Experience collaborating with computational biology teams
- Basic coding skills (R or Python) are a plus
- Interest in translating human biology insights to therapeutics
Tasks
- Design and execute experimental strategies for adaptive immune responses in human neuroinflammation
- Develop in vitro model systems for CNS meningeal inflammation and immune–stromal interactions
- Model disease-relevant immune responses in conditions like multiple sclerosis and Alzheimer’s disease
- Perform deep immune phenotyping and generate multi-omic datasets
- Characterize immune–stromal interactions and define adaptive immune cell states
- Functionally validate and refine in vitro models using human atlases and translational goals
- Collaborate with computational scientists to translate cell states into testable hypotheses
- Iteratively refine in vitro models based on human data
- Engage with IHB and pRED teams to align findings with translational questions in Neuroscience and Rare Diseases
- Contribute to long-term portfolio impact in Neuroscience and Rare Diseases
- Communicate findings through scientific manuscripts, presentations, and cross-functional discussions
- Articulate experimental insights and their relevance to human biology and therapeutic strategy
Work Experience
- approx. 1 - 4 years
Education
- Doctoral / PhD
Languages
- English – Business Fluent
Tools & Technologies
- flow cytometry
- cell sorting
- single-cell RNA-seq
- immune repertoire profiling
- CNS biology
- meningeal biology
- R
- Python
- spectral flow cytometry
- spatial biology
Find the original job posting in its most current version here. Nejo automatically captured this job from the website of Roche and processed the information on Nejo with the help of AI for you. Despite careful analysis, some information may be incomplete or inaccurate. Please always verify all details in the original posting! Content and copyrights of the original posting belong to the advertising company.
Like this job?
BetaYour Career Agent finds similar jobs for you every day.
Not a perfect match?
- Novartis Pharma AG
Principal Scientist - Translational Intestinal Immunology(m/w/x)
Full-timeOn-siteExperiencedBasel - Novartis Pharma AG
Principal Scientist - Translational Intestinal Immunology(m/w/x)
Full-timeOn-siteExperiencedBasel - Institute of Human Biology (IHB)
Post Doctorate Scientist in Intestinal Inflammation(m/w/x)
Full-timeOn-siteSeniorBasel - F. Hoffmann-La Roche AG
Post Doctorate Scientist - Single Cell Technologies(m/w/x)
Full-timeOn-siteSeniorBasel
RORoche
Post Doctorate Scientist (IHB) - In Vitro Modeling Adaptive Immunologist(m/w/x)
Basel
Full-timeOn-siteExperienced
Nejo AI Summary
Designing in vitro models for adaptive immune responses in human neuroinflammation, including MS and Alzheimer's. Deep expertise in adaptive immune biology and hands-on flow cytometry required. Multi-omic dataset generation, cell sorting, and publications track record.
Requirements
- Ph.D. in Immunology, Neuroimmunology/Neuroinflammation, Bioengineering, or related field
- Doctoral studies completed within last four years
- Strong track record of productivity (publications)
- Deep expertise in adaptive immune biology (T-/B-cell biology)
- Strong hands-on flow cytometry and cell sorting experience
- Experience with primary human cells and/or tissue samples
- Experience establishing/working with in vitro model systems
- Experience generating multi-omic datasets (single-cell RNA-seq, immune profiling)
- Interest in downstream data analysis collaboration
- Strong interest in human immunology and neuroinflammation
- Ability to work effectively in collaborative environment
- Strong communication skills
- Professional fluency in English
- Research experience in neuroinflammation (MS, AD)
- Familiarity with CNS and/or meningeal biology
- Experience with stromal cell biology and/or tissue niche interactions
- Experience studying/modeling tertiary lymphoid structures (TLS)
- Experience developing advanced in vitro systems (co-culture, organoids, ex vivo)
- Experience with advanced immune profiling (spectral flow cytometry)
- Exposure to spatial biology workflows or sample preparation
- Experience collaborating with computational biology teams
- Basic coding skills (R or Python) are a plus
- Interest in translating human biology insights to therapeutics
Tasks
- Design and execute experimental strategies for adaptive immune responses in human neuroinflammation
- Develop in vitro model systems for CNS meningeal inflammation and immune–stromal interactions
- Model disease-relevant immune responses in conditions like multiple sclerosis and Alzheimer’s disease
- Perform deep immune phenotyping and generate multi-omic datasets
- Characterize immune–stromal interactions and define adaptive immune cell states
- Functionally validate and refine in vitro models using human atlases and translational goals
- Collaborate with computational scientists to translate cell states into testable hypotheses
- Iteratively refine in vitro models based on human data
- Engage with IHB and pRED teams to align findings with translational questions in Neuroscience and Rare Diseases
- Contribute to long-term portfolio impact in Neuroscience and Rare Diseases
- Communicate findings through scientific manuscripts, presentations, and cross-functional discussions
- Articulate experimental insights and their relevance to human biology and therapeutic strategy
Work Experience
- approx. 1 - 4 years
Education
- Doctoral / PhD
Languages
- English – Business Fluent
Tools & Technologies
- flow cytometry
- cell sorting
- single-cell RNA-seq
- immune repertoire profiling
- CNS biology
- meningeal biology
- R
- Python
- spectral flow cytometry
- spatial biology
Find the original job posting in its most current version here. Nejo automatically captured this job from the website of Roche and processed the information on Nejo with the help of AI for you. Despite careful analysis, some information may be incomplete or inaccurate. Please always verify all details in the original posting! Content and copyrights of the original posting belong to the advertising company.
Like this job?
BetaYour Career Agent finds similar jobs for you every day.
About the Company
Roche
Industry
Pharmaceuticals
Description
The company is dedicated to advancing science and ensuring access to healthcare for everyone.
Not a perfect match?
- F. Hoffmann-La Roche AG
Post Doctoral Scientist (IHB) - Computational Immunology(m/w/x)
Full-timeOn-siteExperiencedBasel - Novartis Pharma AG
Principal Scientist - Translational Intestinal Immunology(m/w/x)
Full-timeOn-siteExperiencedBasel - Novartis Pharma AG
Principal Scientist - Translational Intestinal Immunology(m/w/x)
Full-timeOn-siteExperiencedBasel - Institute of Human Biology (IHB)
Post Doctorate Scientist in Intestinal Inflammation(m/w/x)
Full-timeOn-siteSeniorBasel - F. Hoffmann-La Roche AG
Post Doctorate Scientist - Single Cell Technologies(m/w/x)
Full-timeOn-siteSeniorBasel