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Senior Scientist - Computational Design for Biologics(m/w/x)
Designing biologics for drug discovery using AI-driven protein modeling and molecular dynamics. Deep expertise in antibody design and ML-enabled approaches required. Flexible work models, company daycare centers.
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Anforderungen
- PhD in Computational Biology, Biophysics, Bioinformatics, (Bio-)Chemical Engineering, Structural Biology, or related discipline
- Knowledge of biologics discovery and translation of scientific literature into industrial practice
- Deep expertise in protein/peptide structure modeling, antibody design, molecular dynamics, free-energy and physics-based scoring, and ML-enabled design approaches
- Experience with modern AI tools for co-folding, structure prediction, and de novo binder generation
- Experience working with and interpreting large experimental datasets (binding, functional assays, biophysical characterization, developability screens)
- Strong problem-solving skills
- Effective independent and collaborative work in cross-functional environments
- Enjoyment of working in self-organized teams and taking ownership/accountability
- Experience with large-scale computing environments (HPC/Cloud), container technologies, and workflow orchestration (plus)
- Excellent communication and negotiation skills
- Strong intercultural competence
- Collaborative mindset
- Fluency in English, written and spoken
Aufgaben
- Initiate and drive drug discovery projects
- Support interdisciplinary, cross-functional teams
- Apply structural and biological insights to connect targets with therapeutics
- Define tailored lead-finding strategies
- Characterize protein-protein and protein-ligand interactions
- Identify druggable pockets and epitopes
- Design and optimize antibodies using computational and AI methods
- Collaborate with antibody engineering and machine learning partners
- Build and apply modeling pipelines for various assessments
- Evaluate aggregation and solubility risks
- Assess PTM liability
- Generate and prioritize design hypotheses
- Integrate structural, sequence, biophysical, and assay data
- Develop automated workflows for candidate generation
- Score and select candidates
- Integrate data across programs
- Communicate results through concise reports and visualizations
- Present findings to diverse audiences
- Work closely with wet-lab and IT/HPC stakeholders
Berufserfahrung
Ausbildung
Sprachen
Tools & Technologien
Benefits
- Flexible work models
- Part-time arrangements
- Company daycare centers
- Childcare support
- Summer camps for children
- Time off for family care
- Learning and development opportunities
- Training programs
- Development dialogues
- Coaching programs
- Mentoring programs
- Health checks with company doctor
- Inclusive work environment
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