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RORoche

Topic Lead for Structure Elucidation and Mass Spectrometry(m/w/x)

Basel
VollzeitVor OrtSenior

Analytical detective for structure elucidation using LC-MS and GC-MS to solve structural puzzles. Passionate structure elucidation expert with people leadership skills required. Direct impact on developing new medicines.

Anforderungen

  • Passionate structure elucidation expert with people leadership skills
  • Satisfaction in solving complex structural puzzles
  • Knowledge sharing
  • Thrives in collaborative, high-tech environment
  • Motivated by direct impact on developing new medicines
  • Higher education (Master's or PhD in Chemistry, Biochemistry, or related field)
  • Apprenticeship as laboratory technician
  • Minimum 5 years direct, hands-on experience in structure elucidation
  • Proven leadership skills
  • In-depth experience interpreting high-resolution MS and MS/MS spectra
  • Hands-on skills developing and optimizing chromatographic methods
  • Hands-on skills developing and optimizing mass spectrometry methods
  • Pragmatic, proactive, solution-oriented workstyle
  • Accurate workstyle
  • Balances independent project responsibilities with team collaboration
  • Excellent communication skills
  • Fluency in English
  • Proficiency in German is a plus
  • Keen interest in digital innovation
  • Practical experience with maintenance and troubleshooting of HPLC, GC and MS instrumentation
  • Hands-on experience with 2D-LC-MS
  • Hands-on experience with preparative HPLC
  • Comfortable and experienced working with MS instruments and software from various vendors

Aufgaben

  • Act as an analytical detective for structure elucidation
  • Use LC-MS and GC-MS systems to solve structural puzzles
  • Identify and characterize unknown impurities
  • Serve as topic lead for structure elucidation
  • Provide subject matter expertise for structure elucidation
  • Maintain oversight on structure elucidation requests
  • Collaborate closely with team members
  • Design and execute lab experiments for structure elucidation
  • Elucidate structures of unknown impurities
  • Analyze impurities from process development
  • Analyze impurities from forced degradation studies
  • Analyze impurities from troubleshooting activities
  • Apply expertise in qualitative LC-HRMS
  • Apply expertise in 2D-LC-HRMS
  • Apply expertise in GC-HRMS
  • Analyze complex drug substances
  • Analyze complex drug products
  • Critically evaluate complex analytical data
  • Interpret complex analytical data
  • Provide clear conclusions in English
  • Provide concise conclusions in English
  • Guide project teams with conclusions
  • Support regulatory filings with conclusions
  • Sense future needs for workflows
  • Identify opportunities to enhance workflows
  • Evaluate new software tools
  • Contribute to team development
  • Act as an Enabler by removing barriers
  • Create a successful work environment
  • Partner with project leads
  • Partner with stakeholders
  • Communicate analytical insights directly
  • Ensure analytical insights are understood
  • Integrate analytical insights into project decisions

Berufserfahrung

  • 5 Jahre

Ausbildung

  • Abgeschlossene Berufsausbildung

Sprachen

  • Englischverhandlungssicher
  • DeutschGrundkenntnisse

Tools & Technologien

  • LC-HRMS
  • HPLC
  • GC
  • MS
  • MS/MS
  • 2D-LC-MS
  • GeneData Expressionist
  • ACD/Labs
  • Python
  • JavaScript
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